Month: October 2022

Kobayashi, Kazuhiro; Kozuki, Taketoshi; Konishi, Manami; Suzuki, Teruhiko; Tanmatsu, Miyuki; Konishi, Hisatoshi published an article in Helvetica Chimica Acta. The title of the article was 《Synthesis of 2,3-Diaryl-3H-pyrrolo[2,3-c]pyridin-3-ol Derivatives by the Reaction of Aryl(3-isocyanopyridin-4-yl)methanones with Aryl Grignard Reagents》.Application of 70298-88-3 The author mentioned the following in the article:

The reaction of aryl(3-isocyanopyridin-4-yl)methanones, e.g., I, easily prepared from com. available pyridin-3-amine, with aryl Grignard reagents gave, after aqueous workup, 2,3-diaryl-3H-pyrrolo[2,3-c]pyridin-3-ols. These rather unstable alcs. were O-acylated with Ac2O in pyridine in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) to afford the corresponding 2,3-diaryl-3H-pyrrolo[2,3-c]pyridin-3-yl acetates, e.g., II, in relatively good yields. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sheng, Yuwen; Chen, Yuwen; Zeng, Zhongqiu; Wu, Wenbi; Wang, Jing; Ma, Yuling; Lin, Yuan; Zhang, Jichao; Huang, Yulan; Li, Wenhua; Zhu, Qiyu; Wei, Xiao; Li, Suiyan; Wisanwattana, Wisanee; Li, Fu; Liu, Wanli; Suksamrarn, Apichart; Zhang, Guolin; Jiao, Wei; Wang, Fei published an article on January 13 ,2022. The article was titled 《Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming》, and you may find the article in Journal of Medicinal Chemistry.Synthetic Route of C11H22N2O4 The information in the text is summarized as follows:

Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production In this study, PC was identified as the cellular target of erianin using the photoaffinity labeling-click chem.-based probe strategy. Erianin potently inhibited the enzymic activity of PC, which mediated the anticancer effect of erianin in human hepatocellular carcinoma (HCC). Erianin modulated cancer-related gene expression and induced changes in metabolic intermediates. Moreover, erianin promotes mitochondrial oxidative stress and inhibits glycolysis, leading to insufficient energy required for cell proliferation. Anal. of 14 natural analogs of erianin showed that some compounds exhibited potent inhibitory effects on PC. These results suggest that PC is a cellular target of erianin and reveal the unrecognized function of PC in HCC tumorigenesis; erianin along with its analogs warrants further development as a novel therapeutic strategy for the treatment of HCC. The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Synthetic Route of C11H22N2O4)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Synthetic Route of C11H22N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Chemistry – A European Journal included an article by Moore, Lucas C.; Lo, Anna; Fell, Jason S.; Duong, Matthew R.; Moreno, Jose A.; Rich, Barry E.; Bravo, Martin; Fettinger, James C.; Souza, Lucas W.; Olmstead, Marilyn M.; Houk, Kendall N.; Shaw, Jared T.. Name: 4-Methylbenzenesulfonamide. The article was titled 《Acyclic Stereocontrol in the Additions of Nucleophilic Alkenes to α-Chiral N-Sulfonyl Imines》. The information in the text is summarized as follows:

Diastereoselective Lewis acid-mediated additions of nucleophilic alkenes R(R1)C=CH2 (R = H, Me, OTMS; R1 = Ph, CH2BF3K, CH2TMS) to N-sulfonyl imines (S,E)-R2CH(OR3)CH=NTs (R2 = Me, Ph, Bn; R3 = Me, Bn, TBDPS) are reported. The canonical polar Felkin-Anh model describing additions to carbonyls does not adequately describe analogous additions to N-sulfonyl imines. The development of conditions to produce both syn and anti products syn-R2CH(OR3)CH(NTs)CH2R4 [R4 = CH=CH2, C(O)Ph, CH2=CMe] with high diastereoselectivity and good yields has been described. A stereoelectronic model consistent with exptl. outcomes is also proposed. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T》 were Radhakrishnan, Ramya; Puttaswamy. And the article was published in Chemical Data Collections in 2019. Related Products of 70-55-3 The author mentioned the following in the article:

The kinetics of (IrCl3+PdCl2) bimetallic catalytic mixture as well as individual IrCl3 and PdCl2 catalyzed and uncatalyzed oxidation of kojic acid by sodium-N-chloro-p-toluenesulfonamide (chloramine-T or CAT) in the presence of NaOH has been explored at 298 K. Under identical exptl. conditions, the kinetics for the catalyzed and uncatalyzed reactions was found to unveil varied orders. The rates of catalyzed reactions were found to be 9-38 folds faster than the uncatalyzed reaction. The observed rates of catalyzed reactions called for the existence of synergistic effect in an equimolar mixture of IrCl3+PdCl2. Justifications for the observed results have been provided by plausible mechanisms. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and Antimicrobial and Antioxidant Activities of Sulfonamide Derivatives Containing Tetrazole and Oxadiazole Rings》 were Ozkan, Hamdi; Demirci, Bayram. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 4-Methylbenzenesulfonamide The author mentioned the following in the article:

A new sulfonamide derivative with 1,3,4-oxadiazole moiety and tetrazole ring. I [R = 4-FC6H4S(O)2NH, 4-H3CC6H4S(O)2NH, (4-sulfamoylphenyl)aminyl, etc.] have been synthesized. The biol. activities of resulting compound were also investigated and observed that the compounds reveal strong antimicrobial activity over some important bacterial strains including Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Staphylococcus aureus ATCC 29213. The in vitro antifungal properties of synthesized compounds I, II and III [R1 = H, 2,2-dimethyl-2-((1-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]-1H-1,2,3,4-tetrazol-5-yl)carbamoyl)ethyl] were also a target using Candida albicans NRRL Y-477 and Saccharomyces cerevisiae fungal strains. A useful guideline for future studies about the effect of the chem. structures of sulfonamide compounds on the biol. activities have been provided. Among the target compounds, I (R = 4-FC6H4S(O)2NH, 4-ClC6H4S(O)2NH, 4-BrC6H4S(O)2NH, 4-IC6H4S(O)2NH) demonstrated surprisingly high antimicrobial activities than did others. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects》 was written by Pflimlin, Elsa; Zhou, Zhihong; Amso, Zaid; Fu, Qiangwei; Lee, Candy; Muppiddi, Avinash; Joseph, Sean B.; Nguyen-Tran, Van; Shen, Weijun. HPLC of Formula: 683-57-8 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

The effects of oxytocin on food intake and body weight reduction have been demonstrated in both animal models and human clin. studies. Despite being efficacious, oxytocin is enzymically unstable and thus considered to be unsuitable for long-term use in patients with obesity. Herein, a series of oxytocin derivatives were engineered through conjugation with fatty acid moieties that are known to exhibit high binding affinities to serum albumin. One analog (OT-12) in particular was shown to be a potent full agonist at the oxytocin receptor (OTR) in vitro with good selectivity and long half-life (24 h) in mice. Furthermore, OT-12 is peripherally restricted, with very limited brain exposure (1/190 of the plasma level). In a diet-induced obesity mouse model, daily s.c. administration of OT-12 exhibited more potent anorexigenic and body weight reducing effects than carbetocin. Thus, our results suggest that the long-acting, peripherally restricted OTR agonist may offer potential therapeutic benefits for obesity. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Asymmetric construction of alkaloids by employing a key ω-transaminase cascade》 was written by Taday, Freya; Ryan, James; Argent, Stephen P.; Caprio, Vittorio; Macia, Beatriz; O’Reilly, Elaine. Name: N-Methoxy-N-methylacetamide And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

An ω-transaminase-triggered intramol. aza-Michael reaction has been employed for the preparation of cyclic β-enaminones in good yield and excellent enantio- and diastereoselectivity, starting from easily accessible prochiral ketoynones and com. available enzymes. The powerful thermodn. driving force associated with the spontaneous aza-Michael reaction effectively displaces the transaminase reaction equilibrium towards product formation, using only two equivalent of isopropylamine. To demonstrate the potential of this methodol., this biocatalytic aza-Michael step was combined with annulation chem., affording unique stereo-defined fused alkaloid architectures. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Avadhani, Anusha; Iniyavan, Pethaperumal; Kumar, Yogendra; Ila, Hiriyakkanavar published their research in Journal of Organic Chemistry in 2021. The article was titled 《Single-Pot Preparation of 4-Amino-2-(het)aryl-5-Substituted Thiazoles Employing Functionalized Dithioesters as Thiocarbonyl Precursors》.Name: 2-Bromoacetamide The article contains the following contents:

An effective, diversity oriented, one-pot reaction of 4-amino-2-(het)aryl/alkyl-5-functionalized thiazoles was disclosed, utilizing aryl/heteroaryl/alkyl dithioesters as thiocarbonyl coupling partners in a modified Thorpe-Ziegler type cyclization. The reaction proceeds at room temperature, under mild conditions, in excellent yields, displayed broad functional group compatibility at 2 and 5 positions of thiazoles. This synthetic strategy was further expanded for the one-pot construction of two highly potent tubulin polymerization inhibitors, i.e., 2-(het)aryl-4-amino-5-(3,4,5-trimethoxyaroyl) thiazoles, in high yields. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Artigas, Albert; Castanyer, Cristina; Roig, Nil; Lledo, Agusti; Sola, Miquel; Pla-Quintana, Anna; Roglans, Anna published an article in 2021. The article was titled 《Synthesis of Fused Dihydroazepine Derivatives of Fullerenes by a Rh-Catalyzed Cascade Process》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: 70-55-3 The information in the text is summarized as follows:

A synthetic methodol. was reported that functionalizes C60 and C70 fullerenes with dihydroazepine rings by a cascade reaction encompassing a rhodium-catalyzed cycloisomerization of 1,5-bisallenes and a [4+2] cycloaddition This transition metal-catalyzed cascade reaction provided a versatile and step-economical approach to the synthesis of 6,7-membered polyheterocyclic fullerene adducts. Electrochem. characterization of the products obtained ventures their application in organic and perovskite photovoltaic devices.4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Wang, Yaqian; Liu, Huihui; Yang, Xianhai; Wang, Lianjun published an article in Science of the Total Environment. The title of the article was 《Aquatic toxicity and aquatic ecological risk assessment of wastewater-derived halogenated phenolic disinfection byproducts》.Related Products of 683-57-8 The author mentioned the following in the article:

Increasing number of wastewater-derived aliphatic and phenolic disinfection byproducts (DBPs) were discharged into aquatic environment with the discharge of disinfected wastewater. However, the currently available aquatic toxicity data and the aquatic ecol. risk information of them are limited, especially for wastewater-derived phenolic DBPs. In this study, we investigated the acute toxicity of 7 phenolic DBPs that selected from the typical five groups of phenolic DBPs (2,4,6-trihalo-phenols, 2,6-dihalo-4-nitrophenols, 3,5-dihalo-4-hydroxybenzaldehydes, 3,5-dihalo-4-hydroxybenzoic acids and halo-salicylic acids) and 4 aliphatic DBPs to Gobiocypris rarus and also assessed their potential aquatic ecol. risk. Exptl. results indicated that the half lethal concentration (LC50) values of 2,4,6-trihalo-phenols and 2,6-dihalo-4-nitrophenols ranged from 1 to 10 mg/L; While that of 3,5-dihalo-4-hydroxybenzaldehydes was between 10 and 100 mg/L, and 3,5-dihalo-4-hydroxybenzoic acids and halo-salicylic acids was >100 mg/L. The toxicity mode of action (MOA) identification results from three methods suggested that no clear and consistent MOA were obtained for those 11 DBPs currently. The species-specific aquatic toxicity anal. results highlighted that no aquatic species would be considered as the most sensitive species for all 11 DBPs. However, crustacean and fish were more sensitive than that of algae for most of tested compounds Lastly, the aquatic ecol. risk assessment results of those 11 DBPs revealed that all 7 phenolic and 2 aliphatic DBPs (2-bromoacetamide and bromodichloromethane) had low aquatic ecol. risk, while dichloroacetic acid and dibromoacetonitrile had high aquatic ecol. risk. The low environmental concentration was the main reason why high toxic phenolic DBPs (2,4,6-trihalo-phenols and 2,6-dihalo-4-nitrophenols) exhibited low ecol. risk. Their ecol. risk may increase with the increases of corresponding environmental concentration Thus, more efforts should be made to determine other potential harmful effects of those high toxic phenolic DBPs and to minimize their potential ecol. risk by taking appropriate measures. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8Related Products of 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Related Products of 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics