Month: October 2022

《Structural Diversity in Multinuclear PdII Assemblies that Show Low-Humidity Proton Conduction》 was published in Chemistry – A European Journal in 2014. These research results belong to Samanta, Dipak; Mukherjee, Partha Sarathi. SDS of cas: 64479-78-3 The article mentions the following:

Systematic study on synergetic effects of geometry, length, denticity, and asymmetry of donors was performed through the formation of uncommon PdII aggregates by employing the donor in a multicomponent self-assembly of a cis-blocked 90° PdII acceptor and a tetratopic donor. Some of these assemblies represent the 1st examples of these types of structures, and their formation is not anticipated by only taking the geometry of the donor and the acceptor building units into account. Anal. of the crystal packing of the x-ray structure revealed several H bonds between the counteranions (NO3-) and H2O mols. (O-H···O=N). Also, H-bonded 3-dimensional-networks of H2O are present in the mol. pockets, which show H2O-adsorption properties with some variation in H2O affinity. These complexes exhibit proton conductivity (1.87 × 10-5-6.52 × 10-4 Scm-1) at 296 K and low relative humidity (∼46 %) with activation energies of 0.29-0.46 eV. Also, the conductivities further increase with the enhancement of humidity. The ability of these assemblies to exhibit p-conducting properties under low-humidity conditions makes these materials highly appealing as electrolytes in batteries and in fuel-cell applications. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3SDS of cas: 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.SDS of cas: 64479-78-3 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: H-Lys(Boc)-OHOn November 20, 2020 ,《Decoupling Protein Production from Cell Growth Enhances the Site-Specific Incorporation of Noncanonical Amino Acids in E. coli》 appeared in ACS Synthetic Biology. The author of the article were Galindo Casas, Meritxell; Stargardt, Patrick; Mairhofer, Juergen; Wiltschi, Birgit. The article conveys some information:

The site-specific incorporation of noncanonical amino acids (ncAAs) into proteins by amber stop codon suppression has become a routine method in academic laboratories This approach requires an amber suppressor tRNACUA to read the amber codon and an aminoacyl-tRNA synthetase to charge the tRNACUA with the ncAA. However, a major drawback is the low yield of the mutant protein in comparison to the wild type. This effect primarily results from the competition of release factor 1 with the charged suppressor tRNACUA for the amber codon at the A-site of the ribosome. A number of laboratories have attempted to improve the incorporation efficiency of ncAAs with moderate results. The authors aimed at increasing the efficiency to produce high yields of ncAA-functionalized proteins in a scalable setting for industrial application. To do this, the authors inserted an ncAA into the enhanced green fluorescent protein and an antibody mimetic mol. using an industrial E. coli strain, which produces recombinant proteins independent of cell growth. The controlled decoupling of recombinant protein production from cell growth considerably increased the incorporation of the ncAA, producing substantially higher protein yields vs. the reference E. coli strain BL21(DE3). The target proteins were expressed at high levels, and the ncAA was efficiently incorporated with excellent fidelity while the protein function was preserved.H-Lys(Boc)-OH(cas: 2418-95-3Recommanded Product: H-Lys(Boc)-OH) was used in this study.

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Recommanded Product: H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 4746-61-6On October 31, 1982 ,《Regioselectivity of enzymic O-dealkylation of simple analogs of cholecystographic constrast media》 was published in Drug Metabolism and Disposition. The article was written by Shono, Tatsuya; Ohmizu, Yohko; Toda, Toshiki; Oshino, Nozomu. The article contains the following contents:

The metabolites of N,N’-diphenyl-α,ω-polyoxyethylenedicarboxamides following O-dealkylation by rat liver microsomes were identified by high-performance liquid chromatog. The pattern of metabolism of the dicarboxamides followed the same O-dealkylation pattern as that of iotroxic acid. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Application of 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn October 7, 1983 ,《Regiospecific electrophilic substitution of aminopyridines: ortho lithiation of 2-, 3-, and 4-(pivaloylamino)pyridines》 was published in Journal of Organic Chemistry. The article was written by Turner, James A.. The article contains the following contents:

2- And 4-(Pivaloylamino)pyridines undergo lithiation exclusively at C-3 and then react with a variety of electrophiles to produce 2,3- and 3,4-disubstituted pyridines, resp. Removal of the pivaloyl protecting group results in overall electrophilic substitution of an aminopyridine. Utilization of this method is exemplified by efficient syntheses of 2- and 4-aminonicotinaldehydes. Minor modifications of the reaction conditions permitted exclusive ortho lithiation of 2-(pivaloylamino)pyridines addnl. functionalized by chloro, fluoro, or Me groups. Although the major product from reaction of 3-(pivaloylamino)pyridine by this method was lithiation at C-4, the reaction was complicated by substantial quantities of product derived from nucleophilic attack by BuLi on the pyridine nucleus. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 89281-13-0On May 20, 1999 ,《Design, synthesis and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors》 appeared in Journal of Medicinal Chemistry. The author of the article were Phillips, Gary; Davey, David D.; Eagen, Keith A.; Koovakkat, Sunil K.; Liang, Amy; Ng, Howard P.; Pinkerton, Michael; Trinh, Lan; Whitlow, Marc; Beatty, Alicia M.; Morrissey, Michael M.. The article conveys some information:

A novel series of 2,6-diphenoxypyridine derivatives I ( R = H, 3,5-Cl2, 4-CO3Et, etc.) and II (X = H, 3,5-Cl2) has been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. The evolution from the photochem. unstable bis(amidine) (Z,Z)-BABCH III to potent bis(amidine) compounds with a pyridine heterocycle as the core scaffold has been achieved. The most potent compound in the series, I (X = 3,5-F2-4-Me) (IV), has a Ki for human factor Xa of 12 nM. The selectivity of IV against bovine trypsin and human thrombin was greater than 90- and 1000-fold, resp. Two proposed modes of binding of IV to factor Xa are made based on the crystal structures of IV by itself and of IV bound to bovine trypsin. After reading the article, we found that the author used 2,6-Dichloroisonicotinamide(cas: 89281-13-0SDS of cas: 89281-13-0)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 89281-13-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Brandt, Florian; Ullrich, Martin; Laube, Markus; Kopka, Klaus; Bachmann, Michael; Loeser, Reik; Pietzsch, Jens; Pietzsch, Hans-Juergen; van den Hoff, Joerg; Wodtke, Robert published an article on January 13 ,2022. The article was titled 《”Clickable” albumin binders for modulating the tumor uptake of targeted radiopharmaceuticals》, and you may find the article in Journal of Medicinal Chemistry.Related Products of 2418-95-3 The information in the text is summarized as follows:

The intentional binding of radioligands to albumin gains increasing attention in the context of radiopharmaceutical cancer therapy as it can lead to an enhanced radioactivity uptake into the tumor lesions and, thus, to a potentially improved therapeutic outcome. However, the influence of the radioligand’s albumin-binding affinity on the time profile of tumor uptake has been only partly addressed so far. Based on the previously identified Nε-4-(4-iodophenyl)butanoyl-lysine scaffold, we designed “”clickable”” lysine-derived albumin binders (cLABs) and determined their dissociation constants toward albumin by novel assay methods. Structure-activity relationships were derived, and selected cLABs were applied for the modification of the somatostatin receptor subtype 2 ligand (Tyr3)octreotate. These novel conjugates were radiolabeled with copper-64 and subjected to a detailed in vitro and in vivo radiopharmacol. characterization. Overall, the results of this study provide an incentive for further investigations of albumin binders for applications in endoradionuclide therapies. The experimental process involved the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Related Products of 2418-95-3)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. These amino acids may be present in low concentrations and play a vital part as an intermediate in a biosynthetic pathway, e.g., ornithine, homoserine, or cystathionine. In contrast they may act as a major storage form of nitrogen, e.g., canavanine in the seed of Canavalia ensiformis, or may be formed in high amounts in response to an external stress, e.g., γ-aminobutyrate.Related Products of 2418-95-3 It is possible that some of these nonprotein amino acids may serve as insecticidal or fungicidal agents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1985,Journal of Medicinal Chemistry included an article by Martinez, Jean; Bali, Jean Pierre; Rodriguez, Marc; Castro, B.; Magous, R.; Laur, Jeanine; Lignon, Marie Francoise. Recommanded Product: 87694-50-6. The article was titled 《Synthesis and biological activities of some pseudo-peptide analogs of tetragastrin: the importance of the peptide backbone》. The information in the text is summarized as follows:

Title pseudo-peptide analogs I (Boc = Me3CO2C, R = H) (II), Boc-Trp-NHCH(CH2CHMe2)CH2-Asp-Phe-NH2 (III), and Boc-Trp-Leu-NHCH(CH2CO2H)CH2-Phe-NH2 (IV) were prepared by conventional solution methods. Thus, Boc-Trp-OH was condensed with MeONHMe.HCl by DCC to give Boc-TrpN(OMe)Me, which was reduced by LiAlH4 to give tryptophanal V. R1-Leu-Asp(OCH2Ph)-Phe-NH2 (VI, R1 = Boc) was prepared and then Boc-deblocked to give VI (R1 = H), which was treated with V in the presence of NaBH3CN to give I (R = CH2Ph), which was debenzylated by hydrogenolysis to give II. III was prepared similarly from Boc-Trp-NHCH(CH2CHMe2)CHO and H-Asp(OCH2Ph)-Phe-NH2, whereas PhCH2O2CNHCH(CH2CO2CMe3)CHO was prepared and used in the synthesis of IV. II and III have the same affinity as tetragastrin (VII) for gastrin receptor on isolated mucosal cells, whereas IV exhibited lower affinity. The acid secretion-stimulating activity of I in rats was identical to that of VII; III did not exhibit agonist activity but was able to antagonize the action of gastrin. In the experiment, the researchers used many compounds, for example, (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Recommanded Product: 87694-50-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2010,Chemistry – A European Journal included an article by Tietze, Daniel; Tischler, Marco; Voigt, Stephan; Imhof, Diana; Ohlenschlaeger, Oliver; Goerlach, Matthias; Buntkowsky, Gerd. HPLC of Formula: 87694-50-6. The article was titled 《Development of a Functional cis-Prolyl Bond Biomimetic and Mechanistic Implications for Nickel Superoxide Dismutase》. The information in the text is summarized as follows:

During recent years several peptide-based Ni superoxide dismutase (NiSOD) models have been developed. These NiSOD models show an important structural difference compared to the native NiSOD enzyme, which could cause a completely different mechanism of superoxide dismutation. In the native enzyme the peptide bond between Leu4 and Pro5 is cis-configured, while the NiSOD models exhibit a trans-configured peptide bond between these two residues. To shed light on how the configuration of this single peptide bond influences the activity of the NiSOD model peptides, a new cis-prolyl bond surrogate was developed. As surrogate we chose a leucine/alanine-based disubstituted 1,2,3-triazole, which was incorporated into the NiSOD model peptide replacing residues Leu4 and Pro5. The yielded 1,5-disubstituted triazole nickel peptide exhibited high SOD activity, which was approx. the same activity as its parent trans-configured analog. Hence, the conformation of the prolyl peptide bond apparently has of minor importance for the catalytic activity of the metallopeptides as postulated in literature. Furthermore, it is shown that the triazole metallopeptide is forming a stable cyanide adduct as a substrate analog model complex. The results came from multiple reactions, including the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6HPLC of Formula: 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.HPLC of Formula: 87694-50-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Monty, Olivier B. C.; Nyshadham, Pranavanand; Bohren, Kurt M.; Palaniappan, Murugesan; Matzuk, Martin M.; Young, Damian W.; Simmons, Nicholas published an article on February 10 ,2020. The article was titled 《Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries》, and you may find the article in ACS Combinatorial Science.Reference of H-Lys(Boc)-OH The information in the text is summarized as follows:

Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA-chem. conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that includes a novel aqueous solvent combination to enable reaction homogeneity, an acidic buffer system which masks traditionally problematic functional groups, and a decomposition-resistant catalyst which maximizes conversion to the cyclized product. Addnl., we provide a systematic study of the substrate scope of the on-DNA RCM reaction, a demonstration of its applicability to a single-substrate DNA-encoded chem. library that includes sequencing anal., and the first successful stapling of an unprotected on-DNA [i, i+4] peptide.H-Lys(Boc)-OH(cas: 2418-95-3Reference of H-Lys(Boc)-OH) was used in this study.

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Reference of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Monty, Olivier B. C.; Simmons, Nicholas; Chamakuri, Srinivas; Matzuk, Martin M.; Young, Damian W. published their research in ACS Combinatorial Science on December 14 ,2020. The article was titled 《Solution-phase fmoc-based peptide synthesis for DNA-encoded chemical libraries: Reaction conditions, protecting group strategies, and pitfalls》.Application of 2418-95-3 The article contains the following contents:

Peptide drug discovery has shown a resurgence since 2000, bringing 28 non-insulin therapeutics to the market compared to 56 since its first peptide drug, insulin, in 1923. While the main method of discovery has been biol. display-phage, mRNA, and ribosome-the synthetic limitations of biol. systems has restricted the depth of exploration of peptide chem. space. In contrast, DNA-encoded chem. offers the synergy of large numbers and ribosome-independent synthetic flexibility for the fast and deeper exploration of the same space. Hence, as a bridge to building DNA-encoded chem. libraries (DECLs) of peptides, we have developed substrate-tolerant amide coupling reaction conditions for amino acid monomers, performed a coupling screen to illustrate such tolerance, developed protecting group strategies for relevant amino acids and reported the limitations thereof, developed a strategy for the coupling of α,α-disubstituted alkenyl amino acids relevant to all-hydrocarbon stapled peptide drug discovery, developed reaction conditions for the coupling of tripeptides likely to be used in DECL builds, and synthesized a fully deprotected DNA-decamer conjugate to illustrate the potency of the developed methodol. for on-DNA peptide synthesis. The experimental process involved the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Application of 2418-95-3)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application of 2418-95-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics