Month: October 2022

Wijaya, Mely; Subandi published the artcile< In silico analysis of saponin isolates from mesocarp of cucumber (Cucumic sativus L.) and purple eggplant (Solanum melongena L.) as pancreatic lipase inhibitor>, Related Products of 96829-58-2, the main research area is Cucumic Solanum mesocarp anti obesity pancreatic lipase inhibitor.

Currently orlistat has been widely used as anti-obesity drug, because of its activity as a pancreatic lipase inhibitor. Two saponin isolates, from cucumber mesocarp and purple eggplant, also proved to be active as pancreatic lipase inhibitors in vitro. Based on spectrophotometric anal., the two saponin isolates are thought to be Silphioside F and Cesdiurins I-III. The purpose of this study is to confirm the ability of the two compounds as pancreatic lipase inhibitor through in silico anal., relative to orlistat. This study uses Python Mol. Viewer (PyMol), Python Prescription (PyRx) 0.8, and Discovery Studio software. As a ligand, 3D structure of Silphioside F and Cesdiurins I-III have been used. The orlistat as a comparative ligand mol. have also been used. 3D structure of porsine pancreatic lipase has been used as receptor mol. The result of the anal. shown that the binding site of pancreatic lipase is relatively same as orlistat of Cesdiurins I-III mol., but different for the Silphioside F mol. The data indicated that in inhibiting pancreatic lipase, the two isolate compounds used different mechanism. However, against pancreatic lipase, both mols. have greater binding affinities each, compared to orlistat, which were -9.7 kcal/mol for Silhphioside F and -9.5 kcal/mol for Cesdiurins I-III, and orlistat only -7.6 kcal/mol. The latest data were in line with the in vitro anal., that both isolates have greater inhibition power than orlistat.

IOP Conference Series: Materials Science and Engineering published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Related Products of 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bhargava, P. N.; Prakash, Shree published the artcile< Synthesis of S-substituted-2-mercapto-3-aryl (or aralkyl)-4 (3H) quinazolinones: their CNS and antimicrobial activity>, Related Products of 5326-82-9, the main research area is quinazolinylthioacetamide; thioacetamide quinazolinyl; acetamide quinazolinylthio; central stimulant quinazolinylthioacetamide; bactericide quinazolinylthioacetamide; fungicide quinazolinylthioacetamide; quinazolinethiol chloroacetamide.

Quinazolinylthioacetamides I (R = Ph, 2-MeC6H4, 4-ClC6H4, 4-MeOC6H4, 4-EtOC6H4, R1 = CH2CHMe2, CH2Ph; R = 4-MeC6H4, R1 = CH2CHMe2; R = 3-MeC6H4, PhCH2, R1 = CH2Ph) were obtained by treating quinazolinethiols with ClCH2CONR12. I increased spontaneous motor activity in mice at 600 mg/kg but had no bactericidal or fungicidal activity.

Indian Journal of Pharmacy published new progress about Central nervous system stimulants. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Related Products of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nishad, Chandra Shekhar; Haldar, Krishna Kanta; Banerjee, Biplab published the artcile< Metal-Free Direct Access to N-Sulfonyl Amidines from Sulfonamides and Secondary Amines Involving Tandem C-N Bond Formations>, Recommanded Product: 3-Fluorobenzenesulfonamide, the main research area is sulfonyl amidine preparation metal free one pot; sulfonamide secondary amine tandem carbon nitrogen bond formation.

Authors report a mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives. A wide range of substrates with variety of functional groups is well tolerated under the reaction conditions. Preliminary mechanistic studies indicate that the secondary amine plays a dual role as a C1 source of the amidine group and an aminating agent. Synthetic utility of this method is shown in the late-stage functionalization of drug mols. on the gram scale.

Journal of Organic Chemistry published new progress about Alicyclic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Recommanded Product: 3-Fluorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jiang, Yutong; Andrews, Steven W.; Condroski, Kevin R.; Buckman, Brad; Serebryany, Vlad; Wenglowsky, Steve; Kennedy, April L.; Madduru, Machender R.; Wang, Bin; Lyon, Michael; Doherty, George A.; Woodard, Benjamin T.; Lemieux, Christine; Do, Mary Geck; Zhang, Hailong; Ballard, Joshua; Vigers, Guy; Brandhuber, Barbra J.; Stengel, Peter; Josey, John A.; Beigelman, Leonid; Blatt, Lawrence; Seiwert, Scott D. published the artcile< Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease>, Safety of Morpholine-4-sulfonamide, the main research area is danoprevir macrocyclic peptidomimetic acylsulfonamide preparation inhibitor HCV NS3 protease.

HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human innate immune system. Through structure-based drug design and optimization, macrocyclic peptidomimetic mols. bearing both a lipophilic P2 isoindoline carbamate and a P1/P1′ acylsulfonamide/acylsulfamide carboxylic acid bioisostere were prepared that possessed subnanomolar potency against the NS3 protease in a subgenomic replicon-based cellular assay (Huh-7). Danoprevir (compound 49) was selected as the clin. development candidate for its favorable potency profile across multiple HCV genotypes and key mutant strains and for its good in vitro ADME profiles and in vivo target tissue (liver) exposures across multiple animal species. X-ray crystallog. studies elucidated several key features in the binding of danoprevir to HCV NS3 protease and proved invaluable to the iterative structure-based design strategy of the authors.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Safety of Morpholine-4-sulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hall, Michael E.; Cohen, Jordana B.; Ard, Jamy D.; Egan, Brent M.; Hall, John E.; Lavie, Carl J.; Ma, Jun; Ndumele, Chiadi E.; Schauer, Philip R.; Shimbo, Daichi published the artcile< Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement From the American Heart Association>, Category: amides-buliding-blocks, the main research area is AHA Scientific Statements; blood pressure; metabolic surgery; obesity.

Hypertension is a major risk factor for cardiovascular and renal diseases in the United States and worldwide. Obesity accounts for much of the risk for primary hypertension through several mechanisms, including neurohormonal activation, inflammation, and kidney dysfunction. As the prevalence of obesity continues to increase, hypertension and associated cardiorenal diseases will also increase unless more effective strategies to prevent and treat obesity are developed. Lifestyle modification, including diet, reduced sedentariness, and increased phys. activity, is usually recommended for patients with obesity; however, the long-term success of these strategies for reducing adiposity, maintaining weight loss, and reducing blood pressure has been limited. Effective pharmacotherapeutic and procedural strategies, including metabolic surgeries, are addnl. options to treat obesity and prevent or attenuate obesity hypertension, target organ damage, and subsequent disease. Medications can be useful for short- and long-term obesity treatment; however, prescription of these drugs is limited. Metabolic surgery is effective for producing sustained weight loss and for treating hypertension and metabolic disorders in many patients with severe obesity. Unanswered questions remain related to the mechanisms of obesity-related diseases, long-term efficacy of different treatment and prevention strategies, and timing of these interventions to prevent obesity and hypertension-mediated target organ damage. Further investigation, including randomized controlled trials, is essential to addressing these questions, and emphasis should be placed on the prevention of obesity to reduce the burden of hypertensive cardiovascular and kidney diseases and subsequent mortality.

Hypertension published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jorgensen, Megan M.; Burrell, Brian D. published the artcile< Approaches to studying injury-induced sensitization and the potential role of an endocannabinoid transmitter>, HPLC of Formula: 96829-58-2, the main research area is endocannabinoid transmitter nociception agent nociceptive; Endocannabinoid; Hirudo; Leech; Nociception; Sensitization.

Abstract: Endocannabinoids are traditionally thought to have an analgesic effect. However, it has been shown that while endocannabinoids can depress nociceptive signaling, they can also enhance non-nociceptive signaling. Therefore, endocannabinoids have the potential to contribute to non-nociceptive sensitization after an injury. Using Hirudo verbana (the medicinal leech), a model of injury-induced sensitization was developed in which a reproducible piercing injury was delivered to the posterior sucker of Hirudo. Injury-induced changes in the non-nociceptive threshold of Hirudo were determined through testing with Von Frey filaments and changes in the response to nociceptive stimuli were tested by measuring the latency to withdraw to a nociceptive thermal stimulus (Hargreaves apparatus). To test the potential role of endocannabinoids in mediating injury-induced sensitization, animals were injected with tetrahydrolipstatin (THL), which inhibits synthesis of the endocannabinoid transmitter 2-arachidonoylglycerol (2-AG). Following injury, a significant decrease in the non-nociceptive response threshold (consistent with non-nociceptive sensitization) and a significant decrease in the response latency to nociceptive stimulation (consistent with nociceptive sensitization) were observed In animals injected with THL, a decrease in non-nociceptive sensitization in injured animals was observed, but no effect on nociceptive sensitization was observed

Journal of Comparative Physiology, A: Neuroethology, Sensory, Neural, and Behavioral Physiology published new progress about Analgesia. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lee, Seohoo; Sim, Jaeuk; Jo, Hyeju; Viji, Mayavan; Srinu, Lanka; Lee, Kiho; Lee, Heesoon; Manjunatha, Vishwanath; Jung, Jae-Kyung published the artcile< Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon>, HPLC of Formula: 5004-88-6, the main research area is quinazolinone preparation transition metal free microwave irradiation; dimethyl sulfoxide aminobenzamide intramol oxidative annulation.

Biol. important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramol. oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by this methodol. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.

Organic & Biomolecular Chemistry published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, HPLC of Formula: 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Jie; Bie, Jianbo; Wang, Xiaoyu; Liu, Quan; Li, Rongcui; Chen, Hualong; Hu, Jinping; Cao, Hui; Ji, Wenming; Li, Yan; Liu, Shuainan; Shen, Zhufang; Xu, Bailing published the artcile< Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis>, Application of C6H6FNO2S, the main research area is T2MD liver FBPase inhibitors glucose lowering crystal structure binding.

Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis pathway. Inhibiting FBPase activity represents a potential treatment for type 2 diabetes mellitus. A series of novel N-arylsulfonyl-4-arylamino-indole-2-carboxamide derivatives have been disclosed as FBPase inhibitors. Through extensive structure-activity relationship investigations, a promising candidate mol. Cpd118 [sodium (7-chloro-4-((3-methoxyphenyl)amino)-1-methyl-1H-indole-2-carbonyl] [(4-methoxyphenyl)sulfonyl)amide](I) has been identified with high inhibitory activity against human liver FBPase (IC50, 0.029 ± 0.006 μM) and high selectivity relative to the other six AMP-binding enzymes. Importantly, Cpd118 produced significant glucose-lowering effects on both type 2 diabetic KKAy mice and ZDF rats as demonstrated by substantial reductions in the fasting and postprandial blood glucose levels, as well as the HbA1c level. Furthermore, Cpd118 elicited a favorable pharmacokinetic profile with an oral bioavailability of 99.1%. Moreover, the X-ray crystal structure of the Cpd118-FBPase complex was resolved, which revealed a unique binding mode and provided a structural basis for its high potency and selectivity.

Journal of Medicinal Chemistry published new progress about Bioavailability. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Application of C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Althuis, T. H.; Moore, P. F.; Hess, H. J. published the artcile< Development of ethyl 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylate, a new prototype with oral antiallergy activity>, Formula: C9H12N2O3, the main research area is quinazolinecarboxylate analog preparation antiallergic; allergy inhibitor quinazolinecarboxylate analog; cromoglycate analog allergy inhibitor.

The synthesis and antiallergic activity is described of 18 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid analogs I (R = H, MeO, NO2, Br, etc.; R1 = H or Et; X = CH or N) and II (R = H, CO2Na, CO2Et, OH, etc.; X = CH or N). The title compound II (R = CO2Et, X = N) [55149-04-7] was 10 times more potent (ED50 = 3 mg/kg, orally) than di-Na cromoglycate in the rat passive cutaneous anaphylaxis test. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about Allergy. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Formula: C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Yan-ping; Fei, Zhuan; Liu, Mei-cai; Jia, Feng-cheng; Wu, An-xin published the artcile< Direct One-Pot Synthesis of Luotonin F and Analogues via Rational Logical Design>, Application of C9H12N2O3, the main research area is luotonin F synthesis iodination Kornblum oxidation annulation; quinazolinone acyl derivative preparation.

An efficient one-pot synthetic protocol has been proposed for the synthesis of luotonin F [2-(3-quinolinylcarbonyl)-4(1H)-quinazolinone] from easily available starting materials. Through a rational logical design, multifundamental reactions (iodination, Kornblum oxidation, and annulation) were assembled in one-pot. The developed approach can efficiently synthesize luotonin F and a diversity of analogs.

Organic Letters published new progress about Cyclization. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Application of C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics