Ma, Haowen; Feng, Jiajie; Zhou, Wei; Chen, Chen; Deng, Zhuoji; Zhou, Fengtao; Ouyang, Yifan; Zhang, Xinhao; Cai, Qian published an article in 2021, the title of the article was Copper(I)-catalyzed asymmetric intramolecular C-arylation with ureas as the additives: highly enantioselective formation of spirooxindoles.Application of 102-07-8 And the article contains the following content:
An enantioselective synthesis of spirooxindoles I [Y = CH2, O, NMe; R = Me, allyl, Bn, etc.; R1 = H, 5-F, 6-Me, etc.] via copper-catalyzed asym. intramol. C-arylation reaction with ureas as the co-catalysts was developed. By formation of hydrogen bonds with 1,3-dicarbonyl structures, ureas could activate the substrates, stabilize the carbanion intermediates and the products, and fix the syn-configurations of 1,3-dicarbonyl structures. They help enhance the reactivity, prevent side reactions and improve the enantioselectivities. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8
The Article related to spirooxindole enantioselective preparation, cyclic beta ketoamide preparation copper catalyst ullmann hurtley arylation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Application of 102-07-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics