Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan published an article in 1989, the title of the article was Enantiospecific synthesis of (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline from (+)-(S)-2-methylamino-1-phenylethanol.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide And the article contains the following content:
Acid-promoted cyclization of (+)-(R)-N-(3,4-dimethoxybenzyl)halostachine tricarbonylchomium at -20° is highly stereoselective proceeding with retention of configuration to yield, after removal of the tricarbonylchromium unit, homochiral (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline. In contrast, cyclization of (-)-(R)-N-(3,4-dimethoxybenzyl)halostachine under acidic conditions at -20° showed poor stereoselectivity giving predominantly the tetrahydroisoquinoine product corresponding to inversion of configuration, (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, with an enantiomeric excess of 54%. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide
The Article related to methylaminophenylethanol conversion isoquinoline derivative, isoquinoline derivative stereoselective synthesis, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide
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