On June 30, 2015, Suhasini, K. P.; Christopher, V.; Rao, S. Rama Mohana; Kumar, Ch. Praveen; Murthy, Y. L. N. published an article.COA of Formula: C10H11NO3 The title of the article was Synthesis, characterisation and antitubercular screening of 5(4H)-oxazolone derivatives. And the article contained the following:
In search of new antitubercular agents, a new series of 4-(substituted benzylidene)-2-p-tolyloxazol-5(4H)-ones I [R = C6H5, 4-H3CC6H4, 4-CH3OC6H4, 2,5-(CH3O)2C6H3, 2,4,6-(CH3O)3C6H2, 4-ClC6H4, 4-BrC6H4, O2NC6H4] has been designed, synthesized and subjected to evaluate their antitubercular activity for the first time against Mycobacterium tuberculosis H37Rv, in comparison with standard drugs Rifampicin and Isoniazid. The out-put of these studies disclosed that all the synthesized target mols. I of the series displayed good to moderate activity with MIC values ranging 8-64 U+03BCg/mL. Compound I [R = 2,4,6-(CH3O)3C6H2] having three methoxy groups, is the most distinctive compound identified, amongst the series because of its remarkable in vitro antitubercular activity and thus may act as a promising lead mol. for further explorations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3
The Article related to oxazolone preparation antitubercular, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.COA of Formula: C10H11NO3
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