On October 31, 2010, Mannocci, Luca; Melkko, Samu; Buller, Fabian; Molnar, Ilona; Gapian Bianke, Jean-Paul; Dumelin, Christoph E.; Scheuermann, Jorg; Neri, Dario published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library. And the article contained the following:
Collections of chem. compounds, individually attached to unique DNA fragments serving as amplifiable identification bar codes, are generally referred to as “DNA-encoded chem. libraries”. Such libraries can be used for the de novo isolation of binding mols. against target proteins of interest. Here, we describe the synthesis and use of a DNA-encoded library based on benzamidine analogs, which allowed the isolation of a trypsin inhibitor with an IC50 value of 3.0 nM, thus representing a >10 000-fold potency improvement compared to the parental compound The novel trypsin inhibitor displayed an excellent selectivity toward other serine proteases. This study indicates that DNA-encoded libraries can be used for the facile “affinity maturation” of suboptimal binding compounds, thus facilitating drug development. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid
The Article related to trypsin inhibitor benzamidine derivative dna encoded library, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid
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