Saraiva Rosa, Nathalie published the artcileEnantiopure β3-Trifluoromethyl-β3-homoalanine derivatives: Coupling with Boc-protected amino acids and conformational studies of peptides in solid state, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is amino acid trifluoromethyl methyl enantioselective synthesis tertbutoxycarbonyl protection; peptide coupling conformation hydrogen bond stability crystal structure.
The use of enantiopure β3-trifluoromethyl-β3-alkyl β-amino acids for the design of peptides would contribute to drastically enhance peptide stability in vivo. Moreover, the steric hindrance generated by the substituents on the tetrasubstituted carbon adjacent to the nitrogen function coupled to the electron-withdrawing effect of the trifluoromethyl group is more likely to influence the 3D conformation of the peptide. Herein, we describe a short, scalable and robust method to synthesize N- and/or C-protected enantiopure (R)- and (S)-β3-trifluoromethyl-β3-Me β-amino acid derivatives and liquid-phase coupling methods suitable for incorporation of Boc-protected amino acids into short α/β- and β-peptides. Conformational studies of some of these original peptides via X-ray diffraction anal. highlighted intraresidue C6 hydrogen bonds within trifluoromethylated amino acids.
Synthesis published new progress about Conformation. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.
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