Chen, Wen published the artcileStructure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids, Product Details of C4H11NOS, the main research area is sarpagine ajmaline koumine alkaloid preparation.
A unified approach towards the asym. synthesis of three types of alkaloids, leading to a collective synthesis of 14 natural alkaloids is reported. Among them, akuammidine, 19-Z-akuammidine, vincamedine, vincarine, quebrachidine, vincamajine, alstiphyllanine J, and dihydrokoumine were accomplished for the first time. Features of this synthesis are a new Mannich-type cyclization to construct the key indole-fused azabicyclo[3.3.1]nonane common intermediate, an SmI2-mediated coupling to fuse the aza-bridged E-ring, stereoselective olefinations to install either the 19-E or 19-Z terminal alkenes presented in the natural alkaloids, and an efficient iodo-induced cyclization to establish the two vicinal all-carbon quaternary centers in the koumine-type alkaloids.
Nature Communications published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.
Referemce:
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