Kwiatkowska, Magdalena published the artcileThe self-disproportionation of enantiomers (SDE) via column chromatography of β-amino-α,α-difluorophosphonic acid derivatives, COA of Formula: C4H11NOS, the main research area is aminophosphonic acid ester synthesis self disproportionation enantiomer column chromatog; acetylated benzyloxycarbonyl dipeptide amine SDEvC aminophosphonic acid; hydrogen bond dimer chirality; Achiral chromatography; Amino acids and derivatives; Enantioenrichment/-depletion; Molecular chirality; Self-disproportionation of enantiomers (SDE).
This work presents the first study of the self-disproportionation of enantiomers via chromatog. (SDEvC) of β-aminophosphonic acid esters, several of which have been synthesized for the first time. Three types of structures were examined, N-acetylated, dipeptide construction with N-Cbz (Cbz = benzyloxycarbonyl) glycine, and a free amine. In the latter case, this is the first time that SDEvC has been reported for free amine amino acids. In all the three types of structures, significant SDE magnitudes (Δee’s up to 55%) were exhibited underscoring the ubiquitous nature of the SDE phenomenon. Chem. models of homo- vs. heterochiral intermol. interactions are proposed to rationalize the SDE magnitude differences amongst these new β-aminophosphonic acid derivatives In addition, the incorporation of addnl., competing binding modes to a mol., was found to lead to a reduction of the SDE magnitude by shifting the intermol. binding away from the stereogenic center and/or by leading to a convoluted binding system that disrupts the structured and relatively stable assemblies that give rise to the SDE.
Amino Acids published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, COA of Formula: C4H11NOS.
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