Wang, Huamin published the artcileCatalytic Enantiodivergent Michael Addition by Subtle Adjustment of Achiral Amino Moiety of Dipeptide Phosphines, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is chiral alkylpyridazinone preparation enantioselective; pyridazinone enone hydroamination Michal addition chiral dipeptide phosphine catalyst; Chemistry; Organic Chemistry; Organic Chemistry Methods.
Inspired by the biol. system, an unprecedented catalytic enantiodivergent Michael addition of pyridazinones I (R = H, 5-Cl, 6-Ph, 4,5-Br2, etc.) to enones R1C(O)CH:CHR2 (R1 = 4-chlorophenyl, naphthalen-2-yl, 1-benzothiophen-2-yl, etc.; R2 = CF3, C2F5, C(O)OEt, etc.) by subtle adjustment of achiral amino moiety of dipeptide phosphine catalysts II (R3 = Ph, 3,5-di-tert-butylphenyl; R4 = [3,5-bis(trifluoromethyl)phenyl]carbonyl, (2S)-2-([(tert-butoxy)carbonyl]amino)-3-methylbutanyl, 2-methylpropane-2-sulfinyl, etc.) was reported. These two dipeptide phosphine catalysts, II (R3 = phenyl; R4 = (2S)-2-([(tert-butoxy)carbonyl]amino)-3-methylbutanoyl; R3 = phenyl; R4 = (2S)-2-[(3,5-dinitrophenyl)formamido]-3-methylbutanoyl) could deliver both enantiomers of a series of N2-alkylpyridazinones S/R-III in good yields (up to 99%) with high enantioselectivities (up to 99% ee) via the catalyst-controlled enantiodivergent addition of pyridazinones I to enones R1C(O)CH:CHR2.
iScience published new progress about Dipeptides, phosphono analogs Role: CAT (Catalyst Use), USES (Uses). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics