Polackova, Viera published the artcileN-Sulfinylpyrrolidine-containing ureas and thioureas as bifunctional organocatalysts, Formula: C4H11NOS, the main research area is aldehyde aryl nitroalkene sulfinylpyrrolidine catalyst diastereoselective enantioselective Michael addition; aryl nitroalkane preparation; Michael addition; asymmetric organocatalysis; hydrogen bond; pyrrolidine; thiourea; urea.
The synthesis of bifunctional N-sulfinylureas and thioureas with an appended pyrrolidine unit was presented. These organocatalysts were evaluated in Michael additions of aldehydes to nitroalkenes both under solvent-free conditions and in solution The N-sulfinylurea catalyst was more efficient than the corresponding thiourea. For some substrates, enantioselectivities reached 98% ee. The stereogenic center on the sulfur did not have a considerable influence on the catalytic reactions. Under ball-milling conditions, the Michael adducts were obtained in good yields but with slightly lower enantiomeric purities than in solution DFT calculations elucidated its mode of action and confirmed a dual activation mode, which combines enamine activation of aldehydes and hydrogen bond activation of nitroalkenes.
Beilstein Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics