Shan, Chao published the artcileConstruction of an α-chiral pyrrolidine library with a rapid and scalable continuous flow protocol, COA of Formula: C4H11NOS, the main research area is chloro tert butanesulfinyl imine grignard reagent continuous flow heterocyclization; tert butylsulfinyl pyrrolidine preparation enantioselective diastereoselective.
An α-chiral pyrrolidine library was established via a highly diastereoselective continuous flow protocol under mild conditions. Various functionalized pyrrolidines was obtained in generally high yields (up to 87%) and with superior diastereocontrol within 150 s. The utility of this flow methodol. was further demonstrated by the gram-scale preparation of a κ-opioid receptor selective antagonist Aticaprant intermediate. Moreover, the scale-up in a self-designed microfluidic reactor provided a throughput of 7.45 g h-1, suggesting its potential large-scale applications. The flow procedure afforded rapid, cost-efficient and scalable access to obtain chiral α-substituted pyrrolidines in the compound library.
Reaction Chemistry & Engineering published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, COA of Formula: C4H11NOS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics