Hornink, Milene M. published the artcileUltrasound-mediated radical cascade reactions: fast synthesis of functionalized indolines from 2-(((N-aryl)amino)methyl)acrylates, Quality Control of 123-39-7, the main research area is indoline acetamide methoxycarbonyl preparation green chem; acrylate arylaminomethyl ultrasound radical tandem addition cyclization formamide; Functionalized indolines; Indolines; Organic synthesis; Pulsed ultrasound; Sono-Fenton; Ultrasound.
Novel functionalized indolines were synthesized from 2-(((N-aryl)amino)methyl)acrylates and formamides under ultrasonic irradiation for the first time. Aiming to develop a straightforward and easy-to-implement methodol. for the synthesis of indolines, an instrumentation setup was designed, including ultrasound (US) equipment (Ultrasonic Horn; tip diameter of 12.7 mm, 20 kHz, maximum power of 400 W), an open reaction flask, and an inexpensive and green catalyst (1 mol%; FeSO4·7H2O) without the need for anhydrous conditions. The use of the sono-Fenton process in the presence of formamides and 2-(((N-aryl)amino)methyl)acrylates afforded a broad range of functionalized indolines within 60 s in high yields. Several exptl. parameters of the ultrasound-assisted reaction were evaluated, such as amplitude (40-80%), sonication time (15-60 s), and pulsed ultrasonic irradiation A 60 s silent reaction did not produce the desired indoline. The optimized conditions for US-mediated reactions allowed the production of functionalized indolines in high isolated yields (up to 99%, 60 s reaction time, pulse ratio 1 s:1 s, US amplitude 60%).
Ultrasonics Sonochemistry published new progress about Addition reaction catalysts. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics