Kaczorek, Dorota published the artcileHighly stereoselective synthesis of non-racemic 3-substituted dihydro-benzo[de]isoquinolinones via an addition-cyclization-substitution method, Related Products of amides-buliding-blocks, the main research area is dihydrobenzoisoquionlinone preparation enantioselective; sulfinylimine preparation Grignard reagent addition cyclization substitution reaction.
Substituted dihydrobenzo[de]isoquinolinones (R/S)-I (R = Me, Bu, Ph, 2-methoxy Ph, etc.) were synthesized via diastereoselective addition of Grignard reagents RMgBr to the N-tert-butylsulfinylimine (R/S)-II derived from 1,8-naphthaldehydic Me ester, followed by cyclization and substitution at the sulfur atom. The products were obtained in 25-98% yield and with enantiomeric excess of 46-99%.
Tetrahedron Letters published new progress about Addition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics