Li, Bowen published the artcileNickel-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines, Application In Synthesis of 343338-28-3, the main research area is asym hydrogenation sulfonyl imine nickel catalyst quinoxaline phosphine ligand; amines; asymmetric catalysis; hydrogenation; nickel; reaction mechanisms.
An efficient nickel-catalyzed asym. hydrogenation of N-tert-Bu-sulfonyl imines was developed with excellent yields and enantioselectivities using (R,R)-QuinoxP*, I, as a chiral ligand. The use of a much lower catalyst loading (0.0095 mol %, S/C=10500) represents the highest catalytic activity for the Ni-catalyzed asym. hydrogenations reported so far. Mechanistic studies suggest that a coordination equilibrium exists between the nickel salt and its complex, and that excess nickel salt promotes the formation of the active Ni-complex, and therefore improved the efficiency of the hydrogenation. The catalytic cycle was also investigated by calculations to determine the origin of the enantioselectivity. An extensive network of numerous weak attractive interactions was found to exist between the catalyst and substrate in the transition state and may also contribute to the high catalytic activity.
Angewandte Chemie, International Edition published new progress about Enantioselective synthesis. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application In Synthesis of 343338-28-3.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics