Mazur, Marzena published the artcileDevelopment of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases, Related Products of amides-buliding-blocks, the main research area is aminotriazolyl piperidin amine preparation chitinases inhibitor respiratory system disease.
Acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1) are two enzymically active proteins produced by mammals capable of cleaving the glycosidic bond in chitin. Based on the clin. findings and animal model studies, involvement of chitinases has been suggested in several respiratory system diseases including asthma, COPD, and idiopathic pulmonary fibrosis. Exploration of structure-activity relationships within the series of 1-(3-amino-1H-1,2,4-triazol-5-yl)-piperidin-4-amines, which was earlier identified as a scaffold of potent AMCase inhibitors, led us to discover highly active dual (i.e., AMCase and CHIT1) inhibitors with very good pharmacokinetic properties. Among them, compound 30 was shown to reduce the total number of cells in bronchoalveolar lavage fluid of mice challenged with house dust mite extract after oral administration (50 mg/kg, qd). In addition, affinity toward the hERG potassium channel of compound 30 was significantly reduced when compared to the earlier reported chitinase inhibitors.
Journal of Medicinal Chemistry published new progress about Allergic respiratory disease. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics