McDaniel, Jade published the artcileDiscovery of annulating reagents enabling the one-step and highly stereoselective synthesis of cyclopentyl and cyclohexyl cores, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is carbocycle stereoselective preparation tertbutylsulfinyl chlorobutanimidate bromopentanimidate Michael acceptor cycloaddition.
The use of the unprecedented annulating reagents Me N-(tert-butylsulfinyl)-4-chlorobutanimidate and Me N-(tert-butylsulfinyl)-5-bromopentanimidate enables the diastereoselective preparation of 5- and 6-membered carbocycles bearing three contiguous stereocenters. These synthons undergo cycloaddition with a variety of Michael acceptors to form cyclopentane/cyclohexane rings with excellent stereochem. control, generating only one of the eight possible diastereomers. This novel methodol. has enabled the highly enantioselective and high yielding synthesis of novel chemotypes of pharmacol. relevance.
Organic Letters published new progress about Cycloaddition reaction. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics