Nie, Xiao-Di published the artcileA diastereoselective approach to amino alcohols and application for divergent synthesis of dolastatin 10, Formula: C4H11NOS, the main research area is amino alc enantioselective diastereoselective synthesis; chiral imine radical addition benzyloxymethylsulfonyl pyridine catalyst samarium diiodide; dolastatin synthesis antitumor agent chirality peptide coupling.
A diastereoselective approach to obtain amino alcs. through SmI2-induced radical addition of chiral imine with 2-(benzyloxymethylsulfonyl)pyridine is described. This approach was easily used for the synthesis of non-natural amino acid (I) hydrochloride, a flexible key fragment whose utility was demonstrated in the divergent synthesis of dolastatin 10 and its nine analogs were obtained.
Organic Chemistry Frontiers published new progress about Addition reaction catalysts (SmI2). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics