Ren, Siru published the artcileUse of Gamithromycin as a Chiral Selector in Capillary Electrophoresis, Product Details of C2H5NO, the main research area is gamithromycin chiral selector capillary electrophoresis; Antibiotics; Capillary electrophoresis; Chiral selector; Enantioseparation; Gamithromycin; Non-aqueous.
In this short communication, the authors report the use of a second-generation macrolide antibiotic, gamithromycin (Gam), as a novel chiral selector for enantioseparation in capillary electrophoresis (CE). A preliminary anal. of the experiment results shows that Gam is especially suitable for the separation of chiral primary amines. Factors influencing enantioseparations were systematically studied including the composition of the background electrolyte (BGE), concentration of Gam, the type and proportion of organic solvents, applied voltage, etc. In particular, N-Methylformamide (NMF) was successfully used as a non-aqueous solvent for Gam, and is extremely effective for the separation of primaquine (PMQ) and 1-aminoindan (AMI) when used alone or mixed with other commonly used non-aqueous solvents (e.g. methanol). To the authors’ knowledge this was also the first application of NMF as a non-aqueous solvent for antibiotic chiral selectors in CE. The best separations were obtained with 100 mM Tris, 125 mM H3BO3 and 80 mM Gam in methanol/NMF (25:75) solvent for PMQ and AMI, or 80-100 mM Gam in methanol for the other model analytes. Among the analytes, the resolution (Rs) of amlodipine (AML) reached up to 15.65, which is to the authors’ knowledge the highest value ever reported in CE studies for this compound (except for using molecularly imprinted polymers technique).
Journal of Chromatography A published new progress about Capillary electrophoresis. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics