Wu, Long-Fei published the artcilepH-Dependent peptide bond formation by the selective coupling of α-amino acids in water, Formula: C2H5NO, the main research area is peptide one pot synthesis prebiotic evolution life origin; amino acid peptide alanine coupling prebiotic amine methyl isonitrile; carboxylic acid anhydride intermediate amide bond formation; methyl isonitrile mediated reaction mechanism peptide elongation coupling.
A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramol. formation of the amide bond.
Chemical Communications (Cambridge, United Kingdom) published new progress about Amide group (amide bond). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics