Zhang, Lei published the artcileTotal Synthesis of (-)-Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade, Safety of (S)-2-Methylpropane-2-sulfinamide, the main research area is alstofolinine A total synthesis furan oxidation aza Achmatowicz rearrangement; oxidation rearrangement nucleophilic cyclization cascade azabicyclononane core preparation; aza-Achmatowicz rearrangement; furan; indole; natural-product synthesis; selective oxidation.
A reaction cascade of aza-Achmatowicz rearrangement followed by indole nucleophilic cyclization was developed to generate the common indole-fused azabicyclo[3.3.1]nonane core of the macroline family of alkaloids. The key to the success of the strategy relies on the careful manipulation of protecting groups and judicious selection of chemoselective furan oxidation conditions. The synthetic utility was further demonstrated on the asym. total synthesis of (-)-alstofolinine A (I). The compounds were evaluated for their antitumor activity using four cancer cell lines. Differential activities were observed, indicating that indole-containing multicyclic structures can exert potential and selective biomedical properties, justifying them as hit compounds worthy of further development.
Angewandte Chemie, International Edition published new progress about Achmatowicz reaction (aza-). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Safety of (S)-2-Methylpropane-2-sulfinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics