Zhou, Shengchao published the artcileInsights into the Mechanism of Thiol-Triggered COS/H2S Release from N-Dithiasuccinoyl Amines, Synthetic Route of 123-39-7, the main research area is antiinflammatory dithiasuccinoyl amine derivative preparation thiol hydrogen sulfide.
The hydrolysis of carbonyl sulfide (COS) to form H2S by carbonic anhydrase has been demonstrated to be a viable strategy to deliver H2S in a biol. system. Herein, we describe N-dithiasuccinoyl amines as thiol-triggered COS/H2S donors. Notably, thiol species especially GSH and homocysteine can trigger the release of both COS and H2S directly from several specific analogs via an unexpected mechanism. Importantly, two representative analogs Dts-1 and Dts-5 show intracellular H2S release, and Dts-1 imparts potent anti-inflammatory effects in LPS-challenged microglia cells. In conclusion, N-dithiasuccinoyl amine could serve as promising COS/H2S donors for either H2S biol. studies or H2S-based therapeutics development.
Journal of Organic Chemistry published new progress about Anti-inflammatory agents. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics