Zhu, Bo-Han published the artcileRegio- and Stereoselective Synthesis of Diverse 3,4-Dihydro-2-quinolones through Catalytic Hydrative Cyclization of Imine- and Carbonyl-Ynamides with Water, HPLC of Formula: 343338-28-3, the main research area is dihydro quinolone preparation stereoselective regioselective; imine ynamide tandem Mannich reaction copper catalyst; carbonyl ynamide aldol reaction zinc catalyst.
Described herein is an efficient copper-catalyzed tandem alkyne hydration/intramol. Mannich reaction of imine-ynamides 2-N(R)CCR1-4-R2-5-R3C6H2CH=NR4 (R = Ts, 4-bromobenzenesulfonyl; R1 = Me, allyl, Ph, etc.; R2 = H, F, Cl, Me, OMe; R3 = H, Me, Br; R4 = Ts, tert-butylsulfonyl, 2-methylpropane-2-sulfinyl) with water. This method allows efficient and diastereodivergent synthesis of valuable 3,4-dihydro-2-quinolones I with high regio-, diastereo-, and enantioselectivity. Moreover, this hydrative cyclization can also be applicable to the hydrative aldol reaction of carbonyl-ynamides 2-N(R)CCR1-4-R2-5-R3C6H2C(O)R5 (R = Ts, Ms, 4-bromobenzenesulfonyl; R5 = H, Me, Ph) with water to form 3,4-dihydro-2-quinolones II regio- and diastereoselectively by employing zinc as the catalyst.
ACS Catalysis published new progress about Aldol addition, stereoselective (regioselective). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics