Reichard, Holly A. published the artcileDiscovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia, COA of Formula: C4H11NOS, the main research area is amidomethyl benzotriazinone preparation antipsychotic structure activity relationship.
The chem. optimization that led to the discovery and validation of multiple potent and selective in vivo GPR139 agonist tool compounds, including our clin. candidate TAK-041, also known as NBI-1065846. The pharmacol. characterization of these GPR139 agonists in vivo demonstrated GPR139-agonist-dependent modulation of habenula cell activity and revealed consistent in vivo efficacy to rescue social interaction deficits in the BALB/c mouse strain. The clin. GPR139 agonist TAK-041 was being explored as a novel drug to treat neg. symptoms in SCZ.
Journal of Medicinal Chemistry published new progress about Antipsychotics. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, COA of Formula: C4H11NOS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics