Li, Chun-Tian published the artcileRearrangement of N-tert-Butanesulfinyl Enamines for Synthesis of Enantioenriched α-Hydroxy Ketone Derivatives, Formula: C4H11NOS, the main research area is acyclic tertiary hydroxy sulfenyloxy ketone preparation enantioselective; tert butanesulfinyl ketimine methyl triflate cascade enamination methylation rearrangement.
Treating chiral N-tert-butanesulfinyl ketimines with potassium hexamethyldisilazide (or potassium tert-butoxide) and Me triflate gives N-methylated N-tert-butanesulfinyl enamine intermediates that undergo stereoselective [2,3]-rearrangement to afford α-sulfenyloxy ketones I (R = Ph, iPr, 2-furyl, etc.; R’ = Me, allyl, Bn, etc.) with excellent enantiopurities. This cascade of enamination-N-methylation-rearrangement was even used to generate acyclic tertiary α-hydroxy ketones, II bearing two α-substituents showing negligible differences in bulkiness, such as Me and Et groups.
Organic Letters published new progress about Amination. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics