Itagaki, Kiyoshi’s team published research in Journal of Surgical Research in 169 | CAS: 321673-30-7

Journal of Surgical Research published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Computed Properties of 321673-30-7.

Itagaki, Kiyoshi published the artcileEicosanoid-Induced Store-Operated Calcium Entry in Dendritic Cells, Computed Properties of 321673-30-7, the publication is Journal of Surgical Research (2011), 169(2), 301-310, database is CAplus and MEDLINE.

Background: Eicosanoids are generally recognized to exert potent immunomodulatory properties, including effects on T cell, antigen-presenting cell (APC), and dendritic cell (DC) maturation and function. Since DC maturation and function may also be regulated by store-operated calcium entry (SOCE), we hypothesized that the effects of eicosanoids on DC function may in part be regulated through changes in intracellular calcium. Methods: DC derived from the bone marrow of male Balb/ByJ mice cultured for 7 d in the presence of granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4) were used to study the effects of eicosanoids on SOCE and the resulting Ca2+ mobilization. Results: The 5-lipoxygenase (5-LO) products leukotriene B4 (LTB4) and LTD4, but not LTC4, depleted Ca2+ from DC endoplasmic reticulum stores. The specificity of LTB4 and LTD4 on Ca2+ store-depletion was confirmed by the ability of the specific receptor antagonists, LY25583 and MK571, resp., to abrogate Ca2+ store depletion. RT-PCR demonstrated DC receptors for LTB4 (BLT1 and BLT2) and the cysteinyl-LTs (CysLT1, CysLT2, and GPR17). We also detected transient receptor potential canonical (TRPC) 1, 2, 4, and 6 and stromal interaction mol. 1 (STIM1) on CD11c+ DCs, suggesting these proteins also participate in DC SOCE. In contrast, the cyclooxygenase (CO) metabolite PGE2 had no effect on DC Ca2+ mobilization. Conclusions: To our knowledge, these are the first observations of distinct effects of eicosanoids on DC Ca2+ mobilization, which may have important implications for the regulation of DC maturation at sites of immune and non-immune inflammation.

Journal of Surgical Research published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Computed Properties of 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics