Kamble, Sumit B.'s team published research in Organic Chemistry Frontiers in 8

Kamble, Sumit B. published the artcileA single pot organocatalytic diastereoselective synthesis of fluorescent ring fused 2-pyridone decalines via a domino Knoevenagel/Michael/hydro-lactamisation sequence, Formula: C5H8N2O, the publication is Organic Chemistry Frontiers (2021), 8(18), 5032-5039, database is CAplus.

Multifunctional ring fused octahydro 3-CN-2-pyridone I (R = Ph, thiophen-2-yl, 1,3-benzodioxol-5-yl, etc.; R¹ = H, Me, Et) decaline motifs are constructed by a single pot multicomponent, diastereoselective, organocatalytic domino approach. Three consecutive catalytic reaction sequences are presented, wherein L-proline plays a catalytic dual role for Knoevenagel condensation and Michael addition co-operatively with PhCOOH, followed by annulation by hydro-lactamisation. Compounds containing bromine, chlorine, methoxy and methylenedioxy groups showed aggregation-induced fluorescence under long-range UV exposure. The present method is a green synthetic strategy with the following features: high diastereoselectivity (dr > 20), catalytic activity, high yields, cost-effective nature, a simple, mild, and operationally scalable process, and broad substrate scope.

Organic Chemistry Frontiers published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics