Meresaar, Urve published the artcileHydrolysis of amides. Alkaline and general acid catalyzed alkaline hydrolysis of some substituted acetamides and benzamides, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Acta Chemica Scandinavica, Series A: Physical and Inorganic Chemistry (1974), 28(7), 715-22, database is CAplus.
AcNH2, trifluoro- and trichloroacetamide, trimethyl- and triethylammonioacetamide cation, benzamide, 4-nitrobenzamide, and N,N-diethyl-, N-cyclohexyl-, and N-benzyltrifluoroacetamide were hydrolyzed at 25 or 45° in alk. solution at ionic strength 1. The pH-rate profiles show that the rate at high pH values is more than first-order in OH- for the trialkylammonioacetamide cations, the benzamides, and N-benzyltrifluoroacetamide, which can be interpreted as OH–catalyzed breakdown of a substrate-OH- intermediate. In accord with a mechanism involving acid catalyzed breakdown of this intermediate to products, the rate of hydrolysis of these amides and of N,N-diethyltrifluoroacetamide and N-cyclohexyltrifluoroacetamide is enhanced by the presence of H phosphate or H carbonate ions. This makes it possible to determine the rate constants for the formation of the tetrahedral intermediates (k1), and the ratios of the rate constants for the uncatalyzed breakdown of the intermediates to products and for their reversion to reactants (k2/k-1). The k2/k-1 values are largely independent of electronic effects in the acyclic part but depend on such effects from substituents in the amine part. The corresponding parameters (k3/k-1) for the OH–catalyzed breakdown of the intermediates were also determined
Acta Chemica Scandinavica, Series A: Physical and Inorganic Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics