Raldua, Demetrio published the artcileBLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development, Formula: C12H23N3S, the publication is Toxicology Letters (2007), 175(1-3), 1-7, database is CAplus and MEDLINE.
Block lipid transport-1 (BLT-1) is a small chem. widely used to inhibit the transfer of lipids between high-d. lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent phenotype with a twisted notochord, brain ventricle enlargement, and absence of melanization, phenocopying neocuproine-treated, or calamity mutants. This finding supports an unexpected link between copper availability and SR-BI activity. The copper-chelating activity of BLT-1, revealed by its dramatic effect during embryo development, should be considered in any evaluation of the pharmacol. effect of this thiosemicarbazone derivative on SR-BI activity and the potential therapeutic value of this mol.
Toxicology Letters published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Formula: C12H23N3S.
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https://en.wikipedia.org/wiki/Amide,
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