Vivier, Delphine’s team published research in Journal of Medicinal Chemistry in 60 | CAS: 15029-36-4

Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H24INO4, Product Details of C5H8N2O.

Vivier, Delphine published the artcileDevelopment of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity, Product Details of C5H8N2O, the publication is Journal of Medicinal Chemistry (2017), 60(3), 1076-1088, database is CAplus and MEDLINE.

The TWIK-Related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here the authors report the synthesis of a series of substituted acrylic acids (1-54) based on the previous work with caffeate esters. The analogs were evaluated for their ability to modulate TREK-1 channel by electrophysiol. and for their in vivo antinociceptive activity (acetic acid-induced writhing and hot-plate assays), leading to the identification of a series of novel mols. able to activate TREK-1 and displaying potent antinociceptive activity in vivo. The furyl analog I is the most promising of these series.

Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H24INO4, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics