Wan, Lingzi published the artcileNew synthetic method of Saflufenacil, Application of N-Methyl-N-isopropylsulfamoyl amide, the publication is Huaxue Tongbao (2019), 82(9), 826-830, database is CAplus.
The synthetic process of Saflufenacil and its key intermediates is designed and completed, which has the potential for industrial manufacturing The key intermediate N-methyl-N-isopropylaminosulfonamide is prepared by using chlorosulfonyl isocyanate, t-butanol, N-methyl-N-isopropylamine as the starting material. The overall yield of the three-step reaction is about 75%. Then, 2-chloro-4-fluorobenzoic acid was used as a raw material to prepare Saflufenacil by nitration, chloridization, condensation, catalytic hydrogenation reduction, aminolysis and methylation reactions. The total yield of 8 steps is 48.6%, and the purity of the target product is 98.6%. The final products and the intermediates are characterized by NMR and MS.
Huaxue Tongbao published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C15H14Cl2S2, Application of N-Methyl-N-isopropylsulfamoyl amide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics