In silico analysis of medicinal plants against Mycobacterium tuberculosis (MTB) was written by Sathish Kumar, R.;Sankaravel, V.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2018.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:
Tuberculosis (TB) is a deadly infectious disease caused by the Mycobacterium tuberculosis (MTB). Tuberculosis mostly affects the lungs at later stages it also affects other organs. The protein epoxide hydrolase plays a major role in drug metabolism as well as signal processing mol. and therefore has been targeted in the present study. The medicinal plants being a solution for several human ailments, also act as a reservoir for secondary metabolites, has taken its credit as a cure from our ancient times. The compounds reported earlier in the plants Solanum torvum, Piper longum, Morinda citrifolia, Cocos nucifera, Dissotis rotundifolia, Curcuma longa, Aloe vera, Ocimum basillicum, Centella asiatica and Dipterocarpus sublamelatous were analyzed for its possible significant interaction with the target protein using mol. docking studies.The compounds from the plants Solanum torvum, Piper longum, Morinda citrifolia, Cocos nucifera, Dissotis rotundifolia, Curcuma longa, Aloe vera, Ocimum basillicum, Centella asiatica and Dipterocarpus sublamelatous were analyzed using the mol. docking studies ADME-properties, drug-likeness using the Schrodinger software.The docking results were observed which indicated that the compound catechin scored significant G.score of -8.74 Kcal/mol among the other compounds tested. The interactions were observed with amino acid residue tyrosine at two different positions 164 and 272, each of bond length of 2.1Å. The compound Catechin had significant interaction with the target protein, could be further analyzed for stability using mol. dynamics study and in vitro. The future perspective of the study is to determine the stability of the protein-compound complex through dynamics studies. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics