Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor was written by Gaur, Pooja;Tiwari, Neerja;Shanker, Karuna. And the article was included in ACS Agricultural Science & Technology in 2022.Reference of 18836-52-7 The following contents are mentioned in the article:
The present study demonstrates the alternative source for pseudoalkaloids as well as the utilization of the agricultural wastes of Piper longum (PiL) as possible antiobesity agents. HPLC-based bioactivity-guided micro-fractionation of PiL root has resulted in five known compounds, piplartine (1), piperlonguminine (2), piperine (3), piperanine (5), pellitorine (6), and a new compound, piperdardine (4). Isolated compounds (1-6) were evaluated for their pancreatic lipase (PL) inhibitory potential. Pellitorine (PTR) was the most active component with IC50 = 3.35 μg/mL, which inhibited PL reversibly and in a mixed-type manner. The synergistic effect of PTR with orlistat (0.17 μM) was also observed at a concentration lower than 15.70 μM. The findings of Fourier transform IR spectral studies demonstrated the structural compactness of PL with PTR. The thermodn. studies have confirmed the binding interaction of PTR with PL as hydrophobic. Furthermore, mol. docking studies showed that PTR interacted in the catalytic active amino side residue (Ser153-Asp80-His264) of the protein (1ETH) by hydrogen bonds with affinity (ΔG = -7.0 kcal/mol). The findings of the study support PTR as a potential lead for further validation in animal studies to lead toward clin. translation as an anti-obesity supplement. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 18836-52-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics