Kabes, Connor Q.’s team published research in Synthesis in 52 | CAS: 2418-95-3

Synthesis published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Category: amides-buliding-blocks.

Kabes, Connor Q. published the artcileSyntheses of enantiopure 1,2-ethylenediamines with tethered secondary amines of the formula H2NCH2CH[(CH2)nNHMe]NH2 (n = 1 – 4) from α-amino acids: New agents for asymmetric catalysis, Category: amides-buliding-blocks, the publication is Synthesis (2020), 52(21), 3277-3285, database is CAplus.

Tris(hydrochloride) adducts of the title compounds are prepared from the inexpensive α-amino acids H2N(C:O)CH2CH(NH2)CO2H, HO(C:O)(CH2)nCH(NH 2)CO 2H (n = 1, 2), and H2N(CH2)4CH(NH2)CO2H, resp. (steps/overall yield = 5/32%, 7/30%, 7/33%, 5/38%). The NH2 group that is remote from the secondary amine is installed via BH3 reduction of an amide [(C=O)NR2] derived from an α-amino carboxylic acid. The MeNHCH2 units are introduced by BH3 reductions of alkyl carbamate [RO(C:O)NHCH2; R = Et, t-Bu] or amide [MeHN(C:O)] moieties.

Synthesis published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics