Ren, Shijin published the artcileAn exploratory study of the use of multivariate techniques to determine mechanisms of toxic action, Related Products of amides-buliding-blocks, the publication is Ecotoxicology and Environmental Safety (2003), 55(1), 86-97, database is CAplus and MEDLINE.
The most successful quant. structure-activity relationships have been developed by separating compounds by their mechanisms of toxic action (MOAs). However, to correctly determine the MOA of a compound is often not easy. The authors investigated the usefulness of discriminant anal. and logistic regression in determining MOAs. The discriminating variables used were the logarithm of octanol-water partition coefficients (log Kow) and the exptl. toxicity data obtained from Pimephales promelas and Tetrahymena pyriformis assays. Small total error rates were obtained when separating nonpolar narcotic compounds from other compounds, however, relatively high total error rates were obtained when separating less reactive compounds (polar, ester, and amine narcotics) from more reactive compounds (electrophiles, proelectrophiles, and nucleophiles).
Ecotoxicology and Environmental Safety published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.
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https://en.wikipedia.org/wiki/Amide,
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