Zhang, Yuting’s team published research in Journal of Molecular Structure in 1233 | CAS: 1453-82-3

Journal of Molecular Structure published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C16H14O6, Safety of Isonicotinamide.

Zhang, Yuting published the artcileCrystal structure of five solid forms from isonicotinamide and carboxylic acids assembled by classical hydrogen bonds and other noncovalent interactions, Safety of Isonicotinamide, the publication is Journal of Molecular Structure (2021), 130048, database is CAplus.

Cocrystn. of the commonly available isonicotinamide, with carboxylic acids gave a total of 5 new anhydrous and hydrous multicomponent solid forms: (isonicotinamide)2: (suberic acid) [(L)2·(H2sub), H2sub = suberic acid] (1), (isonicotinamide)2: (α-ketoglutaric acid): H2O [(HL+)2·(kga2-)·H2O, kga2- = α-ketoglutarate] (2), (isonicotinamide): (1,2-phenylenediacetic acid) [(L)·(H2pda), H2pda = 1,2-phenylenediacetic acid] (3), (isonicotinamide): (4-nitrophthalic acid) [(HL+)·(Hnpta–), Hnpta– = 4-nitrohydrogenphthalate] (4) and (isonicotinamide)4: (butane-1,2,3,4-tetracarboxylic acid) [(L)4·(H4bta), H4bta = butane-1,2,3,4-tetracarboxylic acid] (5). The 5 solid forms were characterized by XRD, IR and EA and their m.ps. were also reported. Their structural and supramol. aspects are fully analyzed. 2 and 4 are organic salts with only the aryl N in L protonated, 1, 3 and 5 are co-crystals. The crystal packing is interpreted by the strong N-H···O, O-H···N and O-H···O H bonds. The carboxamide dimers were existed in all solid forms by a pair of N-H···O H bonds. Further inspection of the crystal packing told that a different set of addnl. CH-O/CH2-O, CH-N, O-C, O-O, O-N, O-π and π-π associations contribute to the stabilization and expansion of the total high-dimensional (2D-3D) structures. For the delicate balance of the various weak nonbonding interactions these structures adopted homo/hetero supramol. synthons or both and the common R12(7) and R22(8) graph sets were observed in all solid forms due to the interplay of H bonds and noncovalent associations

Journal of Molecular Structure published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C16H14O6, Safety of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics