Anticholinesterases and antioxidant alkamides from Piper nigrum fruits was written by Tu, Yanbei;Zhong, Yujiao;Du, Hongjian;Luo, Wei;Wen, Yaya;Li, Qin;Zhu, Chao;Li, Yanfang. And the article was included in Natural Product Research in 2016.HPLC of Formula: 18836-52-7 The following contents are mentioned in the article:
The anticholinesterase and antioxidant effects of five different extracts of Piper nigrum were evaluated. Twenty-one known alkamides were isolated from active Et acetate extract and investigated for their cholinesterase inhibitory and antioxidant effects. Among them, piperine, piperettine and piperettyline exhibited dual inhibition against AChE and BChE, and feruperine was the most potent selective inhibitor of BChE. Mol. docking simulation was performed to get insight into the binding interactions of the ligands and enzymes. In addition, N-trans-feruloyltyramine contributed to the strongest DPPH radical-scavenging activity. The self-induced Aβ aggregation inhibition of, and was further evaluated. Results indicated that some alkamides could be multifunctional lead candidates for Alzheimer’s disease therapy. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7HPLC of Formula: 18836-52-7).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 18836-52-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics