Separation of Piper kadsura using preparative Supercritical Fluid Chromatography Combined with Preparative Reversed-Phase Liquid Chromatography was written by Xin, Huaxia;Dai, Zhuoshun;Cai, Jianfeng;Ke, Yanxiong;Feng, Jiatao;Fu, Qing;Jin, Yu;Liang, Xinmiao. And the article was included in Chromatographia in 2018.SDS of cas: 18836-52-7 The following contents are mentioned in the article:
We have developed a separation strategy that employed preparative supercritical fluid chromatog. (prep-SFC) combined with preparative reversed-phase liquid chromatog. (prep-RPLC) to purify compounds from Piper kadsura. The complexity of the sample was effectively reduced by two steps of prep-SFC. The key exptl. parameters of prep-SFC were systematically optimized, including an “average-pressure rule” scaling-up method for adjustment of the back pressure of the system. A mixed modifier consisting of ethanol/n-hexane was applied to provide a stable elution. Prep-RPLC was subsequently adopted to purify the SFC fractions due to its good orthogonality with SFC. Furthermore, chiral SFC was used to sep. the structural analogs. As a result, 14 compounds with high purity were obtained from one fraction, including three pairs of diastereoisomers. These data indicate that the separation strategy using prep-SFC combined with prep-RPLC is an effective tool to sep. complex samples such as natural products. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.SDS of cas: 18836-52-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics