Broderius, Steven J. published the artcileUse of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals, HPLC of Formula: 2447-79-2, the publication is Environmental Toxicology and Chemistry (1995), 14(9), 1591-605, database is CAplus.
We have explored the use of 96-h acute toxicity tests with juvenile fathead minnows and primarily binary chem. mixtures to define the primary acute mode of toxic action for diverse industrial organic chems. Our investigation mainly considered the two special cases of noninteractive joint action known as concentration (simple similar) and response (independent) addition The different forms of joint toxicity with binary mixtures were graphically illustrated by isobole diagrams. Designated as the mode of action-specific reference toxicants were 1-octanol, phenol, and 2,4-dinitrophenol. It was observed from binary isobole diagrams that a chem. with a similar primary mode of toxic action to that of a reference toxicant would display a concentration-addition type of joint action with the reference toxicant over the entire mixture ratio range. Dissimilar chems. with very steep concentration-response curves generally showed an interaction that was less-than-concentration additive, but consistently demonstrated a joint toxicity that was greater than predicted by the response-addition model. The more-than-concentration additive complex isoboles that are indicative of interactive toxicity were not commonly observed in our experiments
Environmental Toxicology and Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 2447-79-2.
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https://en.wikipedia.org/wiki/Amide,
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