Jagerovic, Nadine published the artcileDiscovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a Novel in Vivo Cannabinoid Antagonist Containing a 1,2,4-Triazole Motif, Computed Properties of 2447-79-2, the publication is Journal of Medicinal Chemistry (2004), 47(11), 2939-2942, database is CAplus and MEDLINE.
A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. The title compound, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole (I) showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist. Mol. modeling of I was carried out on Δ9-tetrahydrocannabinoic acid B.
Journal of Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.
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