Month: November 2022

Shukla, J. S. published the artcileSynthesis of some enaminonitriles, HPLC of Formula: 15029-36-4, the publication is Journal of the Indian Chemical Society (1978), 55(3), 281-3, database is CAplus.

Reaction of EtO₂CCH₂CN with RNH₂ gave RNHCOCH₂CN (I; R = Me, Et, PhCH₂, naphthyl, etc.). Treatment of I by CH₂:CHCN gave RNHCOC(CN)(CH₂CH₂CN)₂ (same R). The Thorpe-Ziegler cyclization of the latter gave the title compounds II.

Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C18H28B2O4, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Naik, Kuverji Gosai published the artcileCondensation of cyanoacetic ester with some aryl- and alkyl-amines. Preparation of some aryl- and alkyl-substituted cyano-acetamides, Formula: C5H8N2O, the publication is Quarterly Journal of the Indian Chemical Society (1927), 547-51, database is CAplus.

Cyano- aceto-toluidide, m. 125°, m-toluidide, m. 132°, α-naphthylamide, m. 175°, β-naphthylamide, m. 174°, vic-m-xylidide, m. 107°, methylamide, m. 101° and ethylamide, m. 74°, are prepared for the first time. The methods of preparation vary with the basic strength of the amines. In the preparation of the substituted amides of the aromatic acids, Whiteley’s method, as modified by Naik (C. A. 15, 2072) was used. Cyanoacetanilide, m. 198-9° is prepared by refluxing CNCH₂CO₂Et with redistilled NH₂ at 160-70° for 6 hrs. p-Toluidide, similarly prepared, substituting p-MeC₆H₄NH₂ for PhNH₂, m. 180°. Benzylamide, m. 120°.

Quarterly Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Remen, Lubos published the artcilePreparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers, Category: amides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2016), 59(18), 8398-8411, database is CAplus and MEDLINE.

Aryldihydropyrazolecarboxamides such as I were prepared as brain-penetrating T-type calcium channel blockers for potential use as antiepileptic agents; their inhibition of T-type calcium channels over related calcium channels responsible for potential cardiovascular side effects was determined I was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij rat model of generalized nonconvulsive, absence-like epilepsy. I was not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led to prolongation of the PR interval in ECG recordings in rodents.

Journal of Medicinal Chemistry published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gorska, Katarzyna published the artcileLigand dimerization programmed by hybridization to study multimeric ligand-receptor interactions, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(41), 7742-7744, database is CAplus and MEDLINE.

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Seidelmann, O. published the artcileCyclic voltammetric studies on N,N-disubstituted N’-ferrocenoylthioureas and their transition metal complexes, Recommanded Product: Morpholine-4-carbothioamide, the publication is Polyhedron (1998), 17(10), 1601-1610, database is CAplus.

The Fe(II)/Fe(III) redox potentials of N,N-disubstituted N’-ferrocenoylthioureas and the resp. ferrocene-1,1′-dicarbonic acid di-N,N-dialkyl-thioureids are shifted cathodically by complexation of Ni(II), Cu(II), Co(III), Mn(II), Pt(II) and Pd(II). The extent of the shift is more pronounced in the latter ligand class and reaches values up to -0.32 V. The N,N-disubstituted N’-ferrocenoylthioureas exhibit two redox processes in dichloromethane. A mechanistic scheme is proposed. Ferrocene-1,1′-dicarbonic acid di-N,N-dialkyl-thioureids decompose after oxidation in dichloromethane. In contrast, complexes of both ligand types contain quasireversibly oxidizable ferrocene subunits.

Polyhedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C17H20ClN3, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Manicardi, Alex published the artcileA bifunctional monomer for on-resin synthesis of polyfunctional PNAs and tailored induced-fit switching probes, Category: amides-buliding-blocks, the publication is Organic Letters (2016), 18(21), 5452-5455, database is CAplus and MEDLINE.

A synthetic strategy for the production of polyfunctional PNAs bearing substituent groups both on the nucleobase and on the backbone C5 carbon of the same monomer is described; this is based on the use of a tris-orthogonally protected monomer and subsequent solid-phase selective functionalization. This strategy can be used for synthesizing PNAs that are not readily accessible by use of preformed modified monomers. As an example, a PNA-based probe that undergoes a switch in its fluorescence emission upon hybridization with a target oligonucleotide, induced by tailor-made movement of two pyrene substituent groups, was synthesized.

Organic Letters published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Epsztajn, Jan published the artcileApplication of organolithium and related reagents in synthesis. Part I. Reactions of the N,N-dialkylpyridylcarboxylic amides with lithium amides. Regioselective lithiation of N,N-diisopropylpyridylcarboxylic amides, a useful method for synthesis of 2,3- and 3,4-disubstituted pyridines, Name: N,N-Diethylisonicotinamide, the publication is Tetrahedron Letters (1980), 21(49), 4739-42, database is CAplus.

The reactions of N,N-dialkylpyridyl carboxamides I (R = Me, Et, CHMe₂) with Et₂NLi and (Me₂CH)₂NLi were examined Lithiation of I (R = CHMe₂) was regioselective, providing a convenient route to 2,3- and 3,4-disubstituted pyridines. E.g., I (R = CHMe₂, CONR₂ group in 2-position) was regioselectively lithiated by (Me₂CH)₂NLi (Et₂O, -78°, 2 h) to give II (R = Li), which reacted with DMF to give 35% of aldehyde I (R = CHO). The aldehyde reacted with CH₂(CO₂H)₂ in the Doebner modification of the Knoevenagel reaction to give 29% of I (R = CH:CHCO₂H). The lithio derivative II (R = Li) reacted with Ph₂CO to give 81% I (R = CPh₂OH).

Tetrahedron Letters published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Name: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schmied, Fabian-Pascal published the artcileDevelopment and Characterization of Celecoxib Solid Self-nanoemulsifying Drug Delivery Systems (S-SNEDDS) Prepared Using Novel Cellulose-Based Microparticles as Adsorptive Carriers., Computed Properties of 169590-42-5, the publication is AAPS PharmSciTech (2022), 23(6), 213, database is MEDLINE.

Self-nanoemulsifying drug delivery systems (SNEDDS) represent an interesting platform for improving the oral bioavailability of poorly soluble lipophilic drugs. While Liquid-SNEDDS (L-SNEDDS) effectively solubilize the drug in vivo, they have several drawbacks, including poor storage stability. Solid-SNEDDS (S-SNEDDS) combine the advantages of L-SNEDDS with those of solid dosage forms, particularly stability. The aim of the present study was to convert celecoxib L-SNEDDS into S-SNEDDS without altering their release behavior. Various commercially available adsorptive carrier materials were investigated, as well as novel cellulose-based microparticles prepared by spray drying from an aqueous dispersion containing Diacel^® 10 and methyl cellulose or gum arabic as a binder prior to their use. Particle size and morphology of the carrier materials were screened by scanning electron microscopy and their effects on the loading capacity for L-SNEDDS were investigated, and comparative in vitro dissolution studies of celecoxib L-SNEDDS and the different S-SNEDDS were performed immediately after preparation and after 3 months of storage. Among the adsorptive carrier materials, the novel cellulose-based microparticles were found to be the most suitable for the preparation of celecoxib S-SNEDDS from L-SNEDDS, enabling the preparation of a solid, stable formulation while preserving the in vitro release performance of the L-SNEDDS formulation.

AAPS PharmSciTech published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Computed Properties of 169590-42-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Delaine, Tamara published the artcileSynthesis of the Isonicotinoylnicotinamide Scaffolds of the Naturally Occurring Isoniazid-NAD(P) Adducts, Category: amides-buliding-blocks, the publication is Journal of Organic Chemistry (2007), 72(2), 675-678, database is CAplus and MEDLINE.

The first syntheses of the 1-hydroxy-1-(pyridin-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one and the 3-aminocarbonyl-4-isonicotinoyl-1,4-dihydropyridine frameworks present in the isoniazid-NAD(P) adducts are described.

Journal of Organic Chemistry published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Basavalingappa, Vasantha published the artcileMechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid, SDS of cas: 186046-83-3, the publication is Nature Communications (2019), 10(1), 1-11, database is CAplus and MEDLINE.

The variety and complexity of DNA-based structures make them attractive candidates for nanotechnol., yet insufficient stability and mech. rigidity, compared to polyamide-based mols., limit their application. Here, we combine the advantages of polyamide materials and the structural patterns inspired by nucleic-acids to generate a mech. rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphol. and photoluminescent properties. The assembly possesses a unique at. structure, with each guanine head of one mol. hydrogen bonded to the Fmoc carbonyl tail of another mol., generating a non-planar cyclic quartet arrangement. This structure exhibits an average stiffness of 69.6 ± 6.8 N m^-1 and Young’s modulus of 17.8 ± 2.5 GPa, higher than any previously reported nucleic acid derived structure. This data suggests that the unique cation-free “basket” formed by the Fmoc-G-PNA conjugate can serve as an attractive component for the design of new materials based on PNA self-assembly for nanotechnol. applications.

Nature Communications published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, SDS of cas: 186046-83-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics