Month: November 2022

Brown, Alan D. published the artcileThe discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain, HPLC of Formula: 343338-28-3, the main research area is benzimidazole derivative preparation sodium channel blocker pain; Benzimidazole; Inflammatory pain; Na(V)1.8; Neuropathic pain; PF-06305591; SCN10A; Voltage gated sodium channel.

The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers. Subsequent optimization allowed the identification of compound 9, PF-06305591, as a potent, highly selective blocker with an excellent preclin. in vitro ADME and safety profile.

Bioorganic & Medicinal Chemistry published new progress about Analgesics. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

McKerrall, Steven J. published the artcileStructure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain, Quality Control of 343338-28-3, the main research area is pain analgesic chromane arylsulfonamide sodium channel crystal structure pharmacokinetics.

Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation and mitigation of high in vivo clearance. An in vitro hepatotoxicity hazard was identified and resolved through optimization of lipophilicity and LLE to arrive at GNE-616 (24(I)), a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7. I showed a robust PK/PD response in a Nav1.7 dependent mouse model and site-directed mutagenesis was used to identify residues critical for the isoform selectivity profile of I.

Journal of Medicinal Chemistry published new progress about Analgesics. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Goswami, Prithwish published the artcileEfficient access to general α-tertiary amines via water-accelerated organocatalytic multicomponent allylation, Quality Control of 343338-28-3, the main research area is tertiary amine preparation; ketone allyl boronic acid ester benzhydrazide multicomponent allylation organocatalyst; ketoester allyl boronic acid ester benzhydrazide multicomponent allylation organocatalyst; allyl boronic acid ester ketoester amine multicomponent allylation organocatalyst.

A tetrasubstituted carbon atom connected by three sp3 or sp2-carbons with single nitrogen, i.e., the α-tertiary amines I [R = n-Pr, CH2CO2Et, Ph, etc.; R1 = Me, Et, n-Pr, etc.], was an essential structure of diverse naturally occurring alkaloids and pharmaceuticals. The synthetic approach toward ATA structures was intricate, therefore, a straightforward catalytic method had remained a substantial challenge. Herein, an efficient water-accelerated organocatalytic allylation to directly access ATA incorporating homoallylic amine structures I by exploiting readily accessible general ketones/keto esters as useful starting material along with allyl boronic acid esters and benzhydrazide/amines. The synergistic action of a hydrophobic Bronsted acid in combination with a squaramide hydrogen-bonding donor under aqueous condition enabled the facile formation of the desired moiety I. The developed exceptionally mild but powerful system facilitated a broad substrate scope and enabled efficient multi-gram scalability.

Nature Communications published new progress about Allylation. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kumpan, Katerina published the artcileStructure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases, HPLC of Formula: 13958-99-1, the main research area is tankyrase inhibitor anticancer antitumor agent pyrimidine naphthyridine preparation; 7-Aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-one; Crystal structure; Naphthyridinone; TNKS; Tankyrase.

The tankyrase enzymes [i.e., poly(ADP-ribose) polymerase enzymes] are members of the PARP superfamily. They poly(ADP-ribosyl)ate their target proteins using NAD+ as a source of electrophilic ADP-ribosyl units. The three principal protein substrates of the tankyrase enzymes (TRF1, NuMA and axins) are involved in replication of cancer cells. Thus, inhibitors of the tankyrase enzymes may have anticancer activity (antitumor activity). Using a structure-based drug design and by analogy with known 3-aryl-1-isoquinolinone and 2-aryl-4-quinazolinone inhibitors, series of (aryl)naphthyridinone derivatives, (aryl)pyridopyrimidinone derivatives and their tetrahydro-derivatives were synthesized and evaluated in vitro. 7-Aryl-1,6-naphthyridin-5-one derivatives, 3-aryl-2,6-naphthyridin-1-one derivatives and 3-aryl-2,7-naphthyridin-1-ones were prepared by an acid-catalyzed cyclization of the corresponding [(aryl)ethynyl]pyridinecarbonitrile derivatives or reaction of (bromo)pyridinecarboxylic acids with β-diketones, followed by treatment with NH3. The 7-aryl-1,6-naphthyridin-5-ones were methylated at 1-N and reduced to 7-aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-ones. A copper-catalyzed reaction of benzamidines with (bromo)pyridinecarboxylic acids furnished 2-(aryl)pyrido[2,3-d]pyrimidin-4-ones. A condensation of benzamidines with Me 1-benzyl-4-oxopiperidine-3-carboxylate and deprotection gave 2-aryl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ones, aza analogs of the known inhibitor XAV939. Introduction of a ring-nitrogen in the arylnaphthyridinones and the arylpyridopyrimidinones caused >1000-fold loss in activity, compared with their carbocyclic isoquinolinone and quinazolinone analogs (structure-activity relationship). However, the 7-aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-ones showed excellent inhibition of the tankyrase enzymes, with some examples having IC50 = 2 nM. One compound (7-(4-bromophenyl)-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-one) showed 70-fold selectivity for inhibition of tankyrase-2 vs. tankyrase-1. The mode of binding was explored through crystal structures of inhibitors in complex with tankyrase-2.

Bioorganic & Medicinal Chemistry published new progress about Alkylation. 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, HPLC of Formula: 13958-99-1.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Biao published the artcileCost-effective preparation of microporous polymers from formamide derivatives and adsorption of CO2 under dry and humid conditions, Recommanded Product: N-Methylformamide, the main research area is microporous polymer carbon dioxide adsorption polymerization surface area porosity.

Nitrogen-rich microporous polymers that contain different contents of primary, secondary and tertiary amine groups in their networks are prepared via the amine-formamido condensation reaction utilizing formamide, formohydrazide, N-methylformamide and N,N-dimethylformamide as starting monomers to polymerize with melamine, resp., via a facile one-step polymerization reaction in the absence of any catalyst. The resultant four polymers exhibit BET surface areas of 612-748 m2 g-1 and adjustable pores sizes in the range from 0.52 to 1.10 nm. The systematically changed types of amine groups and porosity parameters result in interesting variations of interfacial interactions between the porous surface and CO2 mol., so as to significantly influence the adsorption behavior of CO2 gas. The uptake of CO2 in polymers is up to 14.6 wt% (273 K/1.0 bar) with an outstandingly high CO2/N2 adsorption selectivity of 151. Moreover, after adding a small amount of water vapor in the mixed CO2/N2 gas, the adsorption selectivity CO2/N2 further increases to 173. The adsorption of CO2 and its selectivity over N2 in this series of microporous polymers under both dry and humid conditions are studied and discussed in terms of the type of the amine group on the polymer skeletons, the adsorption mechanism and the porosity parameters.

Polymer Chemistry published new progress about Adsorption. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Karmakar, Anirban published the artcilePolyaromatic Carboxylate Ligands Based Zn(II) Coordination Polymers for Ultrasound-Assisted One-Pot Tandem Deacetalization-Knoevenagel Reactions, Formula: C2H5NO, the main research area is polyaromatic carboxylate ligand zinc coordination polymer Knoevenagel reaction.

Solvothermal reactions between the polyaromatic group containing carboxylic acid pro-ligands 5-{(pyren-1-ylmethyl)amino}isophthalic acid (H2L1) and 5-{(anthracen-9-ylmethyl)amino}isophthalic acid (H2L2) with Zn(NO3)2·6H2O led to the formation of the new 1D coordination polymer [Zn(L1)(NMF)]n (1) and four other coordination polymers, [Zn(L1)(DMF)]n (2), [Zn(L1)(4,4-Bipy)]n (3), [Zn(L2)(DMF)(H2O)2]n·n(H2O) (4) and [Zn2 (L2)2(DMF)(CH3OH)]n (5), which were previously reported by our group. Single crystal X-ray diffraction analyses revealed that the CP 1 has a one-dimensional (1D) double-chain-type structure similar to that of CP 2. For CP 3, the assembly of the Zn(II) ion with a deprotonated L12- ligand and 4,4′-bipyridine produces a 3D network. CP 4 and 5 exhibit 1D linear and 2D layered-type structures. The ultrasound-assisted tandem reactions promoted by CPs have not yet been well studied. Thus, in the present work, we have investigated the catalytic activities of the newly synthesized CP 1, as well as of the other CPs 2-5, towards the tandem deacetalization-Knoevenagel condensation reactions of various acetals under ultrasonic irradiation They proved to be highly efficient, with special emphasis on catalyst 1, which completely converted the substrate (benzaldehyde di-Me acetal) into the desired product (2-benzylidenemalononitrile) after 2 h. The stability of the catalysts, namely regarding the action of ultrasonic radiation, was demonstrated by their reuse, where only a slight loss of activity was observed after four cycles. Heterogeneity was also demonstrated, and no leaching was detected over the various cycles.

Catalysts published new progress about Adsorption. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Polunin, K. E. published the artcileDetection and Neutralization of Unsymmetrical Dimethylhydrazine on the Surface of Construction Materials, Formula: C2H5NO, the main research area is neutralization dimethylhydrazine construction material ozonation.

The construction materials that contacted with unsym. dimethylhydrazine and the desorption solutions obtained when treating the contaminated surface of metals and alloys with water and reagents were studied by chromatog. and mass spectrometry. Neutralization of unsym. dimethylhydrazine was studied using ozone and shungite. Ozonation makes it possible to destroy the toxicant mols. chem. and phys. adsorbed on the surface of metal constructions, due to which they can be reused and utilized. Shungite effectively adsorbs and catalytically decomposes not only unsym. dimethylhydrazine and its transformation products, but also oligomer compounds formed during the storage of hydrazine fuel. Ozonation of spent shungite can increase the efficiency of destructive processes and completeness of its regeneration.

Russian Journal of Physical Chemistry A published new progress about Adsorption. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chu, Qianqian published the artcileStable Indium Pyridylcarboxylate Framework with Highly Selective Adsorption of Cationic Dyes and Effective Nitenpyram Detection, Application of N-Methylformamide, the main research area is carboxypyridinylterephthalate indium metal organic framework preparation crystal mol structure; pyridylcarboxylate indium framework preparation adsorption cationic dye nitenpyram; luminescence carboxypyridinylterephthalate indium framework.

On the basis of an undeveloped asym. pyridylcarboxylate ligand, 2-(2-carboxypyridin-4-yl)terephthalic acid (H3CPTA), an indium pyridylcarboxylate framework, [(Me)2NH2]1.5[In1.5(CPTA)2]·5.5NMF·6H2O (1), is synthesized under solvent thermal conditions. 1 Displays a 3D anionic framework with a large void space, which contains open square channels with a cross section of 14.6 Å and a pore surface decorated with carboxylic oxygen atoms. Depending on the anionic skeleton and high water stability, 1 exhibits high adsorption selectivity and capacity for cationic dyes in aqueous solution Furthermore, the luminescence performance illustrates that 1 has selectivity and sensitivity to nitenpyram with good recyclability.

Inorganic Chemistry published new progress about Adsorption. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Yue published the artcileEnhancing CO2 Electrocatalysis on 2D Porphyrin-Based Metal-Organic Framework Nanosheets Coupled with Visible-Light, Formula: C2H5NO, the main research area is carbon dioxide electrocatalysis porphyrin MOF nanosheet visible light; 2D nanosheets; carbon dioxide reduction; photocoupled electrocatalysis; porphyrin; visualized channels.

2D Catalysts combined with single atom sites are promising candidates to promote CO2 reduction performance, but the ability to target stable materials with distinct structure still remains challenging. Herein, a series of single metal atoms anchored 2D metal-organic framework nanosheets (MOF-NS-M) with visualized and well-ordered mesoporous structures are fabricated and exhibit enhanced CO2 reduction activity and selectivity with the assistance of visible-light. Encouragingly, the CO Faradaic efficiency of MOF-NS-Co exceeds 90% in a wide potential window of -0.5 to -1.0 V vs. RHE and reaches 98.7% with 100 mV pos. shift compared with the result measured under dark. The catalytic kinetics studies show a fast initial electron transfer to CO2 to form *COO-, thanks to the sufficient exposed active sites resulting from the nanosheet nature and adjusted electron transfer pathway caused by the porphyrin photoswitch.

Small Methods published new progress about Adsorption. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Xiangjie published the artcilePreparation and characterization of bovine serum albumin surface-imprinted thermosensitive magnetic polymer microsphere and its application for protein recognition, COA of Formula: C10H16N2O2, the main research area is bovine serum albumin thermosensitivity magnetic microsphere; Bovine serum albumin; Magnetic microspheres; Molecular recognition; Thermosensitivity.

A novel bovine serum albumin surface-imprinted thermosensitive magnetic composite microsphere was successfully prepared by the surface grafting copolymerization method in the presence of temperature-sensitive monomer N-isopropylacrylamide (NIPAM), functional monomer methacrylic acid (MAA) and crosslinking agent N,N’-methylenebisacrylamide (MBA). The structure and component of the thermosensitive magnetic molecularly imprinted microsphere were investigated by transmission electron microscopy (TEM), Fourier transform IR (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetric anal. (TGA). The results of thermosensitivity, adsorption capacity, selectivity and reusability showed the formation of a thermosensitivity grafting polymer layer P(NIPAM-MAA-MBA) on the surface of Fe3O4@SiO2 and the good adsorption capacity and specific recognition for template protein. When the adsorption temperature was higher than the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM), shape memory effect of imprinted cavities would be more effective. In other words, it was more conducive to capture template mols. under this condition and the imprinting factor would be higher. On the other hand, when the desorption temperature was lower than LCST of PNIPAM, the decrease of shape memory effect between imprinted cavities and template mols. would facilitate the release of template mols. from the imprinted cavities. Based on this property, the adsorption and desorption of template mols. could be regulated by system temperature indirectly which benefited from the existence of thermosensitivity imprinting layer.

Biosensors & Bioelectronics published new progress about Adsorption. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, COA of Formula: C10H16N2O2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics