Baba, Mariko’s team published research in Journal of Natural Medicines in 2021-06-30 | CAS: 123-39-7

Journal of Natural Medicines published new progress about Drug toxicity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Baba, Mariko published the artcileCloning of the cytochrome P450 enzyme from Perilla frutescens involved in nothoapiole biosynthesis, Application In Synthesis of 123-39-7, the main research area is Perilla nothoapiole cytochrome P450; Biosynthetic pathway; Cytochrome P450; Molecular cloning; Perilla; Phenylpropanoid; Volatile compound.

Phenylpropanoid volatile components are found in various plants and are useful in medicines, health foods, and fragrances. While the pharmacol. actions and toxicities of these compounds have been investigated, there are few reports of the cloning of genes that encode biosynthetic enzymes involved in substituent formation at diverse positions and numbers Previously, using the expressed sequence tag (EST) libraries of pure perilla strains that have been maintained for over 30 years for their oil type, we characterized the P 450 enzyme that produces an intermediate for dillapiole by adding a hydroxy group to myristicin. In this study, we selected a P 450 enzyme involved in nothoapiole biosynthesis from the EST library. Heterologous expression of this enzyme in yeast showed that it is a hydroxylase that synthesizes an intermediate to produce nothoapiole from apiole and dillapiole. The enzyme has high amino acid sequence similarity with a previously cloned enzyme and is categorized into the CYP71D subfamily. Furthermore, we investigated the presence or absence of essential oil components and intermediates believed to be involved in nothoapiole biosynthesis by component anal. of perilla essential oil using GC-MS to help elucidate the biosynthetic pathway of nothoapiole. Only a small number of plant species contain nothoapiole as their principal component and thus few studies have reported the biosynthetic genes involved or the drug efficacy and toxicity of nothoapiole. The present study will aid in understanding the biosynthesis of phenylpropanoid volatile compounds, thereby contributing to further research on potentially useful compounds such as nothoapiole.

Journal of Natural Medicines published new progress about Drug toxicity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Langone, Deanna’s team published research in Drug Testing and Analysis in 2022-01-31 | CAS: 123-39-7

Drug Testing and Analysis published new progress about Diastereomers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Langone, Deanna published the artcileImpurity profiling of methamphetamine synthesised from α-phenylacetoacetonitrile (APAAN), Safety of N-Methylformamide, the main research area is phenylacetoacetonitrile methamphetamine impurity profiling; APAAN; impurity profiling; methamphetamine.

The rise in popularity of ′designer′ precursor compounds for the synthesis of amphetamine-type stimulants poses a significant challenge to law enforcement agencies. One such precursor is α-phenylacetoacetonitrile (APAAN). APAAN emerged in Europe in 2010 and quickly became one of the most popular precursors for amphetamine synthesis in that region. Previous literature has identified four APAAN-specific impurities formed in the synthesis of amphetamine; however, there is currently no research on the use of APAAN in the synthesis of methamphetamine, which is more likely to be employed in a non-European market. In this study methamphetamine was synthesized via three common clandestine methods: the Leuckart method and two reductive amination methods. We report the identification of five new impurities and two previously identified impurities characteristic for the use of APAAN in the synthesis of methamphetamine. The newly identified impurities were characterised by MS and NMR and determined to be (E)-3-(methylamino)-2-phenylbut-2-enenitrile, 3-(methylamino)-2-phenylbutanenitrile, 3-methyl-2,4-diphenylpentanedinitrile, 2-phenylbutyronitrile and 3-hydroxy-2-phenylbutanenitrile.

Drug Testing and Analysis published new progress about Diastereomers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kumar, T. N. V. Ganesh’s team published research in Pharmaceutical Chemistry Journal in 2019-07-31 | CAS: 123-39-7

Pharmaceutical Chemistry Journal published new progress about Decomposition. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Kumar, T. N. V. Ganesh published the artcileStudy of dolutegravir degradation and spectroscopic identification of products by LCMS, 1H and 13C NMR Techniques, Safety of N-Methylformamide, the main research area is dolutegravir degradation product spectroscopy NMR LC MS.

Stability study for dolutegravir bulk drug was performed and the degradation products formed were identified by chromatog. (HPLC, LCMS) and spectroscopy (ESI-MS, FTIR, 1H and 13C NMR) techniques. Degradation of the drug in acidic and peroxide environment yielded one common major degradant f ((2,4-difluorophenyl) methanamine) with a mass peak at m/z = 182.44. In addition to this, five more minor degradation products (a, b, c, d and e) were formed. The structure interpretation showed that the drug degraded to its synthetic precursor and no extra structures were formed. Hence, it was suggested that drug dolutegravir should be kept away from acidic and oxygen rich conditions.

Pharmaceutical Chemistry Journal published new progress about Decomposition. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Ling’s team published research in ACS ES&T Water in 2021-04-09 | CAS: 123-39-7

ACS ES&T Water published new progress about Decomposition. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Zhu, Ling published the artcileStructure-Dependent Fenton Reactivity and Degradation Pathway of Methylimidazolium Ionic Liquids, Application In Synthesis of 123-39-7, the main research area is methylimidazolium ionic liquid fenton reactivity degradation pathway.

Short-chain imidazolium-based ionic liquids (IBILs) substituted by Me groups are highly water-soluble and have the potential risk of entering the water environment with wastewater. In this work, the structure-dependent Fenton reactivity and degradation pathway of methylimidazolium ionic liquids were investigated, including the influence of the proton activity and structural symmetry of IBILs. The chem. reactivity of specific sites (atoms) was quant. predicted by a condensed Fukui function (fA-). Aprotic IBILs ([DMIM][BF4] and [TMIM][BF4]) were more resistant to the •OH attacks than protic IBILs ([HHIM][BF4] and [HMIM][BF4]) because deprotonation reduced the fA- value of the attack sites. Structural symmetry increased the initial rate of the total organic carbon (TOC) reduction (k0,TOC) due to the existence of sym. Fenton reaction sites. Trimethyl-substituted [TMIM][BF4] showed the lowest TOC removal efficiency and k0,TOC presumably because the C2-Me substitution greatly weakened the fA- value of C2. The plausible mineralization pathways were proposed on the basis of gas chromatog. coupled with mass spectrometry analyses. The more Me substitution resulted in weaker Fenton reactivity but more oxidation pathways. For [TMIM][BF4], C2-Me reduced the Fenton reactivity of the imidazolium skeleton but increased the oxidation opportunities of dual N-methyls. The Fenton reactivity of methylimidazolium ionic liquids (ILs) is regulated by the proton activity and structural symmetry of ILs.

ACS ES&T Water published new progress about Decomposition. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nanduri, V. V. S. S. Raman’s team published research in Journal of Chromatographic Science in 2012 | CAS: 1159977-36-2

Journal of Chromatographic Science published new progress about Decomposition. 1159977-36-2 belongs to class amides-buliding-blocks, name is N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, and the molecular formula is C18H14F4N2O4S, Product Details of C18H14F4N2O4S.

Nanduri, V. V. S. S. Raman published the artcileDevelopment and Validation of Stability-Indicating HPLC and UPLC Methods for the Determination of Bicalutamide, Product Details of C18H14F4N2O4S, the main research area is bicalutamide impurity determination HPLC UPLC tablet stability.

Six new process related impurities (Imp-08, Imp-09, Imp-10, Imp-12, Imp-13, and Imp-14) of bicalutamide (BCT) were reported in this paper. BCT was subjected to oxidative, acid, alk., hydrolytic, thermal, and photolytic degradation conditions and found to degrade in alk. condition, yielding Imp-11. Stability-indicating high-performance liquid chromatog. and ultra-performance liquid chromatog. methods were developed for the determination of BCT in the presence of its 14 process-related impurities and 1 degradant by Zorbax SB Ph column (150 × 4.6 mm × 3.5 μm) and HSS T3 column (100 × 2.1 mm × 1.8 μm), resp. Both the methods were validated as per International Conference on Harmonization guidelines. Quantitation limits (QL) were found be in the ranges of 0.02-0.03% for both the methods. Precision was evaluated by replicate anal. in which % relative standard deviation (RSD) values for areas were found <2.0. Linearity for the impurities was established in the range of QL to 200% of the specification level and the correlation coefficients derived from of the resp. calibration curves were approx. 0.999. The recoveries obtained for purity (90-100%) and assay (98-102%) ensured the accuracy of the developed methods. Journal of Chromatographic Science published new progress about Decomposition. 1159977-36-2 belongs to class amides-buliding-blocks, name is N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, and the molecular formula is C18H14F4N2O4S, Product Details of C18H14F4N2O4S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boettcher, Stephan’s team published research in European Journal of Organic Chemistry in 2014 | CAS: 125328-80-5

European Journal of Organic Chemistry published new progress about Deacetylation. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, Application In Synthesis of 125328-80-5.

Boettcher, Stephan published the artcileIndoxylic Acid Esters as Convenient Intermediates Towards Indoxyl Glycosides, Application In Synthesis of 125328-80-5, the main research area is dye pigment indoxyl glycoside preparation glycosylation decarboxylation silver catalyst.

Indoxylic acid Me and allyl esters with varied halide-substitution patterns were obtained in excellent yields using a scalable route. Phase-transfer glycosylation of these key intermediates was carried out with various glycosyl halides. Subsequent mild silver-mediated decarboxylation followed by Zemplen deacetylation led to indoxyl glycosides, e.g. I, in good overall yields. Indoxyl glycosides are well-established and widely used tools for enzyme screening and enzyme-activity monitoring. In the past, their synthesis has been difficult, so this new approach has led to a variety of useful structures.

European Journal of Organic Chemistry published new progress about Deacetylation. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, Application In Synthesis of 125328-80-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Ling-Nan’s team published research in Combustion and Flame in 2019-04-30 | CAS: 123-39-7

Combustion and Flame published new progress about Carbonization. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Wu, Ling-Nan published the artcileExperimental and kinetic study on the low-temperature oxidation of pyridine as a representative of fuel-N compounds, Formula: C2H5NO, the main research area is pyridine oxidation temperature kinetics.

The low-temperature oxidation (LTO) of pyridine was studied in a jet-stirred reactor over the temperature range of 700-1000 K at atm. pressure and equivalence ratio of 2.0. Mole fraction profiles of the reaction products were obtained based on mol. beam mass spectrometry and tunable vacuum UV synchrotron photoionization techniques. Hydrogen peroxide, methanamine, acetylenamine, ethenamine, acetaldimine, ethylamine, allyamine, and methylformamide were newly identified compared with previous studies of pyridine flame and pyrolysis. HCN was found to be the dominant N-containing species of pyridine LTO. Pyrrole, acrylonitrile, acetonitrile, and ammonia were also found at the same level of N2O and NO. Based on the new measurements and updated rate constants of several reactions including the H-abstractions of pyridine as well as the oxidation of ortho-pyridyl using d. functional theory calculations, a new pyridine LTO kinetic model consisting of 588 species and 3516 reactions was developed with a reasonable agreement with the exptl. results. In general, the predictions of the predominant species have been improved compared with the existing model. Rate-of-production anal. indicates that pyridine mainly consumes via C5H5N→C5H4N→C5H4NO2→HCN+CO+CH2CHC→O, and C5H5N→C5H5NO→C2H2+HCN+CH2CO. Sensitivity anal. shows that C5H4N+O2 = >C5H4NO2, and C5H5N+OH=C5H4N+H2O have significant promoting effect on pyridine consumption, while the reverse of C5H4N+HO2=C5H4NO+OH has strong inhibiting effect. The results will enrich the understanding of pyridine low-temperature oxidation mechanism, which can be applied to the fields of coal pre-treatment, staged combustion and mild combustion.

Combustion and Flame published new progress about Carbonization. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jersovs, Glebs’s team published research in Organic Letters in 2022-07-01 | CAS: 343338-28-3

Organic Letters published new progress about Bond cleavage. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Jersovs, Glebs published the artcileSynthetic Approach toward Enantiopure Cyclic Sulfinamides, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is sulfinamide haloalkenyl diastereoselective cyclization tert butyl cleavage; cyclic sulfinamide asym synthesis oxidation alkylation.

A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers has been developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral SVI derivatives such as sulfoximines and sulfonimidamides is demonstrated.

Organic Letters published new progress about Bond cleavage. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kunwar, Deepak’s team published research in Thin Solid Films in 2022-09-01 | CAS: 123-39-7

Thin Solid Films published new progress about Boiling point. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Kunwar, Deepak published the artcileEffects of solvents on synthesis of piezoelectric polyvinylidene fluoride trifluoroethylene thin films, Application of N-Methylformamide, the main research area is solvent effect piezoelec PVDF TrFE thin film dissolution.

Polyvinylidene Fluoride (PVDF) and its co-polymer formulations, such as tri-fluoroethylene (TrFE) have been extensively researched as a thin flexible piezoelec. material for a wide range of applications, and new methods of synthesizing the material are continuously being investigated. Researchers have used various solvents to synthesize the PVDF film, yet the effects of these solvents on the piezoelec. properties have not been systematically investigated. The selection of an optimized solvent for polymer dissolution can affect film properties, which could lead to enhanced device performance for piezoelec.-based microsystems. Herein, several solvents were screened for the dissolution of PVDF-TrFE polymer to investigate the effect of solvents and to determine key properties of the solvents that influence the piezoelec. response, so further enhancements can be made in the future. This study investigated 14 different solvents with varying physicochem. properties. The thin films were characterized via X-ray diffraction and quasi-static piezometer measurements. This paper reports that the piezoelec. coefficient of the thin film was highly dependent on the solvent′s dipole moment. Our observation revealed that the solvent with the highest dipole moment that was able to completely dissolve the PVDF-TrFE powder produced the film with the highest piezoelec. coefficient The spin coated film decreased thickness with increasing spin speed, and the piezoelec. coefficient was not affected by the thickness of the film in the range of 1-5 μm.

Thin Solid Films published new progress about Boiling point. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Carmona-Espindola, Javier’s team published research in Journal of Chemical Physics in 2020-03-31 | CAS: 123-39-7

Journal of Chemical Physics published new progress about Atomic charge. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Carmona-Espindola, Javier published the artcileConstrained dipole moment density functional theory for charge distributions in force fields for the study of molecular fluids, Computed Properties of 123-39-7, the main research area is constrained dipole moment DFT charge distribution force field fluid; MD MM simulation constrained dipole moment DFT mol fluid.

A new procedure, based on electronic structure calculations that only requires a dipole moment value for a given mol. as input and, from which the charges for all the atoms in it are uniquely determined, is developed and applied to the study of mol. fluids with classical dynamics. The dipole moment value considered for the isolated mol. is the one that reproduces the dielec. constant of its corresponding fluid. Following previous work, the Lennard-Jones parameters are determined to reproduce the liquid d. and the surface tension at the liquid-vapor interface. The force field thus obtained leads to a reasonable description of several properties such as heats of vaporization, self-diffusion coefficients, shear viscosities, isothermal compressibilities, and volumetric expansion coefficients of pure substances. (c) 2020 American Institute of Physics.

Journal of Chemical Physics published new progress about Atomic charge. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics