Month: November 2022

Li, James J. published the artcileDiscovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications, HPLC of Formula: 125328-80-5, the main research area is pyrroloimidazolidinone hydroxy preparation muscle selective androgen receptor modulator.

A novel series of imidazolin-2-ones was designed and synthesized as highly potent, orally active and muscle selective androgen receptor modulators (SARMs), with most of the compounds exhibiting low nM in vitro potency in androgen receptor (AR) binding and functional assays. Once daily oral treatment with the lead compound I (AR Ki = 0.9 nM, EC50 = 1.8 nM) for 14 days induced muscle growth with an ED50 of 0.09 mg/kg, providing approx. 50-fold selectivity over prostate growth in an orchidectomized rat model. Pharmacokinetic studies in rats demonstrated that the compound I had oral bioavailability of 65% and a plasma half-life of 5.5 h. On the basis of their preclin. profiles, the SARMs in this series are expected to provide beneficial anabolic effects on muscle with minimal androgenic effects on prostate tissue.

Journal of Medicinal Chemistry published new progress about Anabolic agents. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, HPLC of Formula: 125328-80-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Grunewald, Gary L. published the artcileApplication of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine N-Methyltransferase: Balancing pKa and Steric Effects in the Optimization of 3-Methyl-1,2,3,4-tetrahydroisoquinoline Inhibitors by β-Fluorination, Related Products of amides-buliding-blocks, the main research area is tetrahydroisoquinoline SAR preparation THIQ adrenoceptor PNMT.

3-Methyl-1,2,3,4-tetrahydroisoquinolines (3-methyl-THIQs) are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT), but are not selective due to significant affinity for the α2-adrenoceptor. Fluorination of the Me group lowers the pKa of the THIQ amine from 9.53 (CH3) to 7.88 (CH2F), 6.42 (CHF2), and 4.88 (CF3). This decrease in pKa results in a reduction in affinity for the α2-adrenoceptor. However, increased fluorination also results in a reduction in PNMT inhibitory potency, apparently due to steric and electrostatic factors. Biochem. evaluation of a series of 3-fluoromethyl-THIQs and 3-trifluoromethyl-THIQs showed that the former were highly potent inhibitors of PNMT, but were often nonselective due to significant affinity for the α2-adrenoceptor, while the latter were devoid of α2-adrenoceptor affinity, but also lost potency at PNMT. 3-Difluoromethyl-7-substituted-THIQs have the proper balance of both steric and pKa properties and thus have enhanced selectivity vs. the corresponding 3-fluoromethyl-7-substituted-THIQs and enhanced PNMT inhibitory potency vs. the corresponding 3-trifluoromethyl-7-substituted-THIQs. Using the “”Goldilocks Effect”” analogy, the 3-fluoromethyl-THIQs are too potent (too hot) at the α2-adrenoceptor and the 3-trifluoromethyl-THIQs are not potent enough (too cold) at PNMT, but the 3-difluoromethyl-THIQs are just right. They are both potent inhibitors of PNMT and highly selective due to low affinity for the α2-adrenoceptor. This seems to be the first successful use of the β-fluorination of aliphatic amines to impart selectivity to a pharmacol. agent while maintaining potency at the site of interest.

Journal of Medicinal Chemistry published new progress about Pharmacokinetics. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guan, Aocong published the artcileSolubility of Phthalic Acid and o-Toluic Acid in Seven Organic Solvents: Experimental Measurement and Thermodynamic Modeling, Formula: C2H5NO, the main research area is solubility phthalic acid toluic acid organic solvent.

In this study, the solubility of phthalic acid and o-toluic acid in propionic acid, N-methylformamide, N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMAC), DMSO, N-methylpyrrolidone (NMP), and acetonitrile are measured under atm. pressure (101.3 kPa) by the method of laser dynamics. The exptl. temperature range is 286.35 to 338.75 K. The measured data shows that the solubility of phthalic acid and o-toluic acid increases with increasing temperature in the temperature range studied. The exptl. data are correlated by the Apelblat model, the λh model, and the modified nonrandom two liquid activity coefficient model, and the calculated solubility is in agreement satisfactorily with the measured results. Akaike information criterion anal. results show that the Apelblat model was the most suitable model to correlate the solubility of phthalic acid in propionic acid, N-methylformamide, and DMSO and the solubility of o-toluic acid in propionic acid, DMSO, and NMP; the λh model was the most suitable model to correlate the solubility of phthalic acid in DMF and DMAC and the solubility of o-toluic acid in N-methylformamide and DMF; and the modified NRTL model was the most suitable model to correlate the solubility of phthalic acid in NMP and acetonitrile and the solubility of o-toluic acid in DMAC and acetonitrile.

Journal of Chemical & Engineering Data published new progress about Organic solvents. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yousefinejad, Saeed published the artcileStructure-electrochemistry relationship for monovalent alkaline metals in non-aqueous solutions, SDS of cas: 123-39-7, the main research area is structure electrochem relationship monovalent alkanic metal non aqeous solution.

Electrochem. methods, which deal with the interrelation of chem. and elec. properties, are interesting because of numerous advantages. Here, the electrochem. behavior of three important single-at. metallic monovalent ions (Li+, Na+, K+) were modelled in some organic solvents based on quant. structure electrochem. relationships. Because the inorganic ions have not mol. structure, only structural information of organic solvents was involved in the model. Q2 of cross validation were 0.95, 0.88 and 0.82 in lithium, sodium and potassium models, resp., and the R2test were 0.97, 0.89 and 0.93 in lithium, sodium and potassium models, resp. Various validation approaches were used to evaluate the proposed linear models. The results not only are useful for the prediction and estimation of the voltammetric behavior of the studied cations but also give a way to descript the important features of the utilized organic solvents on the half wave potential of lithium, sodium and potassium.

Physics and Chemistry of Liquids published new progress about Electrochemistry. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gonzalez-Castro, Raul A. published the artcileEffects of extender, cryoprotectants and thawing protocol on motility of frozen-thawed stallion sperm that were refrozen for intracytoplasmic sperm injection doses, Recommanded Product: N-Methylformamide, the main research area is intracytoplasmic sperm injection refrozen glycerol methylformamide cryopreservation extender; Cryoprotectant; Freezing; Refreezing; Sperm; Stallion; Thawing.

We examined the effects of different freezing extenders, cryoprotectant agents (CPA) and initial thawing temperatures for preparing doses of refrozen stallion sperm for intracytoplasmic sperm injection (ICSI). Single ejaculates, from twelve stallions, were frozen in lactose-EDTA-egg yolk extender (LE) with 5% glycerol. In experiment 1, sperm were initially thawed to 5°C or 37°C, before being diluted in LE or skim milk-egg yolk extender (SMEY) containing either 5% glycerol (GLY), 5% methylformamide (MF) or 5% of a combination of both (GMF). In experiment 2, frozen sperm were initially thawed to 5°C, diluted and refrozen in SMEY containing 2, 4, 6 or 8% GLY or GMF. In Experiment 1, sperm motility was reduced after each cryopreservation cycle (P < 0.05). Extender type did not affect motility after refreezing (P > 0.05), but sperm initially thawed to 5°C exhibited higher motility than sperm thawed to 37°C (P < 0.05). In addition, sperm refrozen in SMEY containing MF or GMF exhibited higher motility than sperm refrozen in GLY alone (P < 0.05). In experiment 2, there was an interaction between CPA and CPA concentration (P < 0.05). Sperm refrozen with GMF had higher motility than refrozen sperm with GLY (P < 0.05), and while GLY concentration did not affect post-thaw motility (P > 0.05). Sperm refrozen with 6 or 8% GMF exhibited the highest motility (P < 0.05). In conclusion, sperm motility is best maintained when thawing and refreezing stallion sperm in low sperm concentration ICSI doses by initially thawing the sperm to 5°C and diluting the sperm in a freezing extender with 8% GMF. Theriogenology published new progress about Cryopreservation. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gslamoglu, Fatih published the artcileCalculation of thermodynamic properties of the most important forty-seven different solvents to create an information data bank through semi-empirical quantum methods used in determination of theoretical pKa, Computed Properties of 123-39-7, the main research area is solvent data bank semi empirical quantum method thermodn.

In this study, we have calculated the thermodn. properties, especially in determining the theor. acidic properties and pKa values of organic compounds, as enthalpy (ΔH, kcal/mol), heat capacity (C, cal/Kmol), entropy (ΔS, cal/Kmol), and free energy (ΔG kcal/mol) of 47 different solvents with the MOPAC 2016 computer program at 298 K used in semi-empirical quantum methods (PM7, PM6, PM6-DH2, RM1, PM3, AM1, and MNDO). Evaluations are made between these values and the used methods. At the same time, a data bank is created with obtained values for the researchers who will do scientific study for the theor. pKa.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about Computer program. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Meischner, M. published the artcileSoil VOC emissions of a Mediterranean woodland are sensitive to shrub invasion, Name: N-Methylformamide, the main research area is Cistus Quercus soil VOC acetaldehyde acetone methanol; Cistus ladanifer ; Quercus suber ; PTR-TOF-MS; Soil VOCs; litter; soil moisture; soil respiration.

Many belowground processes, such as soil respiration and soil-atm. VOC (volatile organic compounds) exchange, are closely linked to soil microbiol. processes. However, little is known about how changes in plant species cover, i.e. after plant invasion, alter these soil processes. In particular, the response of soil VOC emissions to plant invasion is not well understood. We analyzed soil VOC emissions and soil respiration of a Mediterranean cork oak (Quercus suber) ecosystem, comparing soil VOC emissions from a non-invaded Q. suber woodland to one invaded by the shrub Cistus ladanifer. Soil VOC emissions were determined under controlled conditions using online proton-transfer time-of-flight mass spectrometry. Net soil VOC emissions were measured by exposing soils with or without litter to different temperature and soil moisture conditions. Soil VOC emissions were sensitive to C. ladanifer invasion. Highest net emission rates were determined for oxygenated VOC (acetaldehyde, acetone, methanol, acetic acid), and high temperatures enhanced total VOC emissions. Invasion affected the relative contribution of various VOC. Methanol and acetaldehyde were emitted exclusively from litter and were associated with the non-invaded sites. In contrast, acetone emissions increased in response to shrub presence. Interestingly, low soil moisture enhanced the effect of shrub invasion on VOC emissions. Our results indicate that shrub invasion substantially influences important belowground processes in cork oak ecosystems, in particular soil VOC emissions. High soil moisture is suggested to diminish the invasion effect through a moisture-induced increase in microbial decomposition rates of soil VOC.

Plant Biology (Berlin, Germany) published new progress about Cistus ladanifer. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Yijun published the artcileA novel and efficient asymmetric synthesis of anti-HIV drug maraviroc, Computed Properties of 343338-28-3, the main research area is maraviroc antiHIV drug preparation enantioselective.

A novel and efficient route to asym. synthesis of maraviroc by using (S)-tert-butanesulfinamide as chiral auxiliary is described. Two interesting impurities of the process are isolated and identified. The synthesis was concise, mild, and easy to operate. The overall yield and stereoselectivity were excellent.

Synthetic Communications published new progress about Chiral auxiliary. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Computed Properties of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Prasad, Kavirayani R. published the artcileStereoselective addition of Grignard reagents to sulfinimines derived from tartrate diol (threitol): Generation of chiral building blocks for the collective total synthesis of lentiginosine, conhydrine and methyldihydropalustramate, Product Details of C4H11NOS, the main research area is stereoselective Grignard sulfinimine threitol sulfinimine; lentiginosine synthesis; conhydrine synthesis; methyl dihydropalustramate synthesis.

A systematic investigation of the addition of Grignard reagents to sulfinimines derived from tartaric acid diol was undertaken. It was observed that the chirality of the inherent tartrate moiety influences the diastereoselectivity of the resultant sulfinamides formed in the reaction. The formed products serve as excellent building blocks for the synthesis of natural products. This has been demonstrated in the collective total synthesis of lentiginosine, (+)-α-conhydrine and Me dihydropalustramate (I – III, resp.).

Tetrahedron published new progress about Chiral auxiliary. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

DeGreeff, Lauryn E. published the artcileCanine olfactory detection of trained explosive and narcotic odors in mixtures using a Mixed Odor Delivery Device, Recommanded Product: N-Methylformamide, the main research area is canine olfactory detection trained explosive narcotic odor delivery device; Canine olfaction detection; Explosives detection; Headspace analysis; Narcotics detection; SPME-GC/MS.

Like using a substandard calibrant to test and calibrate an instrumental detector, when detection canines are regularly exposed to less than optimal training material, their detection proficiency is diminished, risking the lives of their handlers and civilians they are intended to protect. This research examined canine detection proficiency to odor mixtures and the use of mixture training to improve said proficiency. Trained detection canines were tested on their ability to correctly locate their trained target odors, explosives or narcotics, in various mixtures from a series of blanks and distractor odors. After making base measurements, canines were trained on the target odor in mixtures using the Mixed Odor Delivery Device (MODD), which was previously developed to safely contain separated explosive components and deliver the mixed odor to a canine detector for training purposes. Headspace measurements, made using solid phase microextraction with gas chromatog./mass spectrometry (SPME-GC/MS), were also taken of mixture components in and out of the MODD to confirm that odor mixtures were accurately portrayed to the canines during MODD training. Following mixture training, canines were retested on the same mixtures Results of the headspace anal. showed that the MODD did not alter the delivery of the odorants from the mixture components. As such, canines showed an improved proficiency in detection of target mixtures following mixture training, increasing the detection rate from 63% to 72% for pseudo cocaine mixtures and from 19% to 100% for explosive mixtures

Forensic Science International published new progress about Canis familiaris. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics