Month: November 2022

Sang, Wenjiao published the artcileDegradation of liquid phase N,N-dimethylformamide by dielectric barrier discharge plasma: Mechanism and degradation pathways, Recommanded Product: N-Methylformamide, the main research area is DMF liquid phase degradation dielec barrier discharge wastewater treatment; Degradation pathways; Dielectric barrier discharge (DBD) plasma; Hydroxyl radical; Liquid phase; N,N-dimethylformamide (DMF).

The degradation of liquid phase N,N-dimethylformamide (DMF) using the dielec. barrier discharge (DBD) plasma was studied in the present study. The results showed that 1000 mg L-1 DMF could be degraded by DBD plasma under different input power, treatment time and initial pH values of aqueous solution After 40 min with DBD plasma discharge, 52.2% degradation efficiency was achieved at DMF concentration of 1000 mg L-1 with an input power of 16.19 W under initial pH of 11.14 in aqueous solution, and the energy efficiency of the system was 13.2 mg kJ-1. The removal efficiency decreased with the presence of radical scavenger, manifesting that ·OH plays a critical role in the degradation process. The value of TOC in DMF aqueous solution decreased from 790 mg L-1 to 507 mg L-1 in 40 min, which indicated that DBD plasma has the ability to mineralize a portion of DMF in liquid directly. Addnl., the anal. of FTIR, HPLC and the small mol. organic compounds before and after the DBD plasma degradation indicated that the intermediates of DMF in degradation process were N-methylformamide, methanol, formaldehyde and formic acid, which were finally mineralized into ammonia nitrogen, CO2 and H2O. Moreover, the possible degradation mechanism and pathways were proposed.

Chemosphere published new progress about Dielectric barrier discharge. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quintavalla, Arianna published the artcileDiastereoselective Synthesis of Chiral Oxathiazine 2-Oxide Scaffolds as Sulfinyl Transfer Agents, Synthetic Route of 343338-28-3, the main research area is chiral oxathiazine oxide preparation diastereoselective sulfinyl transfer agent.

An efficient diastereoselective route for the preparation of chiral oxathiazine 2-oxide scaffolds as sulfinyl transfer agents, using tert-butanesulfinamide (tBSA) both as the source of chirality and as the precursor to the required nitrogen electron withdrawing group on the scaffold, was developed. This methodol. allows the introduction of different substituents on the chiral scaffold, using com. available reagents and standard synthetic transformations. The synthesized scaffolds were tested in the preparation of enantioenriched sulfinamides, providing results comparable to the sulfinyl transfer agents so far proposed in the literature, and opening the possibility to further elaborate these scaffolds, with the aim to support them on solid phases so to facilitate their recovery and reuse.

Advanced Synthesis & Catalysis published new progress about Diastereoselective synthesis. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yisimayili, Nuermaimaiti published the artcileα-Hydroxylation of α,α-Disubstituted N-tert-Butanesulfinyl Ketimines with Molecular Oxygen: Stereoselective Synthesis of α-Tertiary Hydroxyimines, Related Products of amides-buliding-blocks, the main research area is tertiary hydroxyimine preparation diastereoselective; acyclic ketimine hydroxylation.

The α-tertiary hydroxyimines (Rs/Ss,2R)-ROHC(R1)C=NS(O)t-Bu (R = butan-2-yl, cyclohex-3-en-1-yl, 1-phenylpropyl, etc.; R1 = Ph, 2-propenyl, 2-methoxyphenyl, etc.) were stereoselectively synthesized from enantioenriched N-tert-butanesulfinyl ketimines (Rs/Ss,2R)-RCH(R1)C=NS(O)t-Bu using potassium tert-butoxide, mol. oxygen, and tri-Me phosphite. The stereoselective hydroxylation of acyclic ketimines bearing two sterically similar α-substituents was achieved by controlling the geometry of the metalloenamine intermediates and the facial selectivity of hydroxylation. The synthetic utility of the resulting α-tertiary hydroxyimines was demonstrated through the successful diastereoselective synthesis of highly substituted β-amino alcs.

Organic Letters published new progress about Diastereoselective synthesis. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Harten, Paul published the artcileFinding Potential Replacements for TRI Solvents Using the Environmental Impact of the Average Solvent, Formula: C2H5NO, the main research area is toxics release inventory solvent potential replacement; Environmental impacts; Health impacts; Solvent substitution; Solvents.

A solvent has many different types of impact on the environment. This article describes a method that combines several different types of impacts together into one environmental index so that similar solvents may be compared by their cumulative impact to the environment. The software tool PARIS III (Program for Assisting the Replacement of Industrial Solvents III) initially finds thousands of solvents mixtures with behaviors as close as possible to those of the original solvent entered. The overall environmental impacts of these solvent mixtures are estimated and assigned to environmental indexes. Users of the software tool can then choose replacements for the original solvent with similar activities but with significantly smaller environmental indexes. These solvent mixtures may act as practical substitutes for the industrial solvents but substantially reduce the overall environmental impact of the original harmful solvents. Potential replacements like this are found for three of the U.S. Environmental Protection Agency’s Toxic Release Inventory solvents, carbon tetrachloride, toluene, and N-methylpyrrolidone.

Journal of Solution Chemistry published new progress about Computer program (PARIS III). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Madron du Vigne, Adrien published the artcileChiral Cyclic Alkyl Amino Carbene (CAAC) Transition-Metal Complexes: Synthesis, Structural Analysis, and Evaluation in Asymmetric Catalysis, HPLC of Formula: 343338-28-3, the main research area is chiral cyclic alkyl amino carbene CAAC transition metal complex; asym catalysis chiral cyclic alkyl amino carbene transition metal; conjugate borylation asym alpha beta unsaturated ester copper carbene; crystal mol structure cyclic alkyl amino carbene transition metal.

Despite recent advances in the field of cyclic alkyl amino carbenes (CAACs) including a few complementary synthetic strategies affording CAACs with various substitution patterns, the application potential of chiral CAACs to efficiently catalyze asym. organometallic transformations remains largely underdeveloped. Herein, authors describe a convenient and robust route that incorporates common chiral primary amine allowing access of a broad range of chiral CAACs precursors. The corresponding transition-metal complexes with Cu, Au, Ru, Rh, Ir, and Pd were obtained in a straightforward manner. The steric parameters of the complexes were comprehensively collected by x-ray single-crystal anal. to serve as a source of information for further ligand design. The preliminary application potential of the copper CAAC complexes was tested in asym. conjugate borylation of an α,β-unsaturated ester providing 89:11 er, thus illustrating the potential of chiral CAACs in asym. catalysis.

Organometallics published new progress about Borylation (asym. conjugate). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mazur, Marzena published the artcileDevelopment of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases, Related Products of amides-buliding-blocks, the main research area is aminotriazolyl piperidin amine preparation chitinases inhibitor respiratory system disease.

Acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1) are two enzymically active proteins produced by mammals capable of cleaving the glycosidic bond in chitin. Based on the clin. findings and animal model studies, involvement of chitinases has been suggested in several respiratory system diseases including asthma, COPD, and idiopathic pulmonary fibrosis. Exploration of structure-activity relationships within the series of 1-(3-amino-1H-1,2,4-triazol-5-yl)-piperidin-4-amines, which was earlier identified as a scaffold of potent AMCase inhibitors, led us to discover highly active dual (i.e., AMCase and CHIT1) inhibitors with very good pharmacokinetic properties. Among them, compound 30 was shown to reduce the total number of cells in bronchoalveolar lavage fluid of mice challenged with house dust mite extract after oral administration (50 mg/kg, qd). In addition, affinity toward the hERG potassium channel of compound 30 was significantly reduced when compared to the earlier reported chitinase inhibitors.

Journal of Medicinal Chemistry published new progress about Allergic respiratory disease. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Abis, Letizia published the artcileMeasurement report: biogenic volatile organic compound emission profiles of rapeseed leaf litter and its secondary organic aerosol formation potential, Category: amides-buliding-blocks, the main research area is volatile organic compound emission aerosol rapeseed leaf litter.

We analyzed the biogenic volatile organic compound (BVOC) emissions from rapeseed leaf litter and their potential to create secondary organic aerosols (SOAs) under three different conditions, i.e., (i) in the presence of UV light irradiation, (ii) in the presence of ozone, and (iii) with both ozone and UV light. These experiments were performed in a controlled atm. simulation chamber containing leaf litter samples, where BVOC and aerosol number concentrations were measured for 6 d. Our results show that BVOC emission profiles were affected by UV light irradiation which increased the summed BVOC emissions compared to the experiment with solely O3. Furthermore, the diversity of emitted VOCs from the rapeseed litter also increased in the presence of UV light irradiation SOA formation was observed when leaf litter was exposed to both UV light and O3, indicating a potential contribution to particle formation or growth at local scales. To our knowledge, this study investigates, for the first time, the effect of UV irradiation and O3 exposure on both VOC emissions and SOA formation for leaf litter samples. A detailed discussion about the processes behind the biol. production of the most important VOC is proposed.

Atmospheric Chemistry and Physics published new progress about Aerosols (secondary organic). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gao, Yejun published the artcileAn efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp3)-H bond activation mediated by Selectfluor, SDS of cas: 123-39-7, the main research area is aryl ketone anthranil DMSO selectfluor three component reaction; aroyl quinoline preparation.

An efficient method for the synthesis of 3-functionalized quinolines from com. available ketones and anthranil was described. Selectfluor propeled the C(sp3)-H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in moderate to high yields. DMSO acts not only as a solvent but also as a one carbon donor in the reaction.

RSC Advances published new progress about [4+2] Cycloaddition reaction. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cinelli, Maris A. published the artcileCorrection to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors [Erratum to document cited in CA166:529893], Safety of (S)-2-Methylpropane-2-sulfinamide, the main research area is aminoquinoline derivative preparation nNOS inhibitor neurodegenerative disorder erratum.

In the original publication on Page 3975, Under the paragraph heading “”Inhibitor Complex Crystal Preparation””, lines 9-10 state “”… for human eNOS, 12-15% PEG3350, 0.1 M Bis-Tris, pH 6.5, …”” should read “”… for human eNOS, 12-15% PEG3350, 0.1 M Bis-Tris, pH 7.5, …””; the correction is provided here.

Journal of Medicinal Chemistry published new progress about Central nervous system agents. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Safety of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Spinn, Alexander published the artcileCharge Anisotropy of Nitrogen: Where Chemical Intuition Fails, Product Details of C2H5NO, the main research area is charge anisotropy nitrogen atom ammonia amine amide force field.

For more than half a century computer simulations were developed and employed to study ensemble properties of a wide variety of at. and mol. systems with tremendous success. Nowadays, a selection of force-fields is available that describe the interactions in such systems. A key feature of force-fields is an adequate description of the electrostatic potential (ESP). Several force-fields model the ESP via point charges positioned at the atom centers. A major shortcoming of this approach, its inability to model anisotropies in the ESP, can be mitigated using addnl. charge sites. It has been shown that nitrogen is the most problematic element abundant in many polymers as well as large mols. of biol. origin. To tackle this issue, small organic mols. containing a single nitrogen atom were studied. In performing rigorous scans of the surroundings of these nitrogen atoms, positions where a single extra charge can enhance the ESP description the most were identified. Significant improvements are found for ammonia, amines, and amides. Interestingly, the optimal location for the extra charge does not correlate with the chem. intuitive position of the nitrogen lone pair. In fact, the placement of an extra charge in the lone-pair location does not lead to significant improvements in most cases.

Journal of Chemical Theory and Computation published new progress about Amides Role: PRP (Properties). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics