Kaczorek, Dorota’s team published research in Tetrahedron Letters in 2020-06-25 | CAS: 343338-28-3

Tetrahedron Letters published new progress about Addition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.

Kaczorek, Dorota published the artcileHighly stereoselective synthesis of non-racemic 3-substituted dihydro-benzo[de]isoquinolinones via an addition-cyclization-substitution method, Related Products of amides-buliding-blocks, the main research area is dihydrobenzoisoquionlinone preparation enantioselective; sulfinylimine preparation Grignard reagent addition cyclization substitution reaction.

Substituted dihydrobenzo[de]isoquinolinones (R/S)-I (R = Me, Bu, Ph, 2-methoxy Ph, etc.) were synthesized via diastereoselective addition of Grignard reagents RMgBr to the N-tert-butylsulfinylimine (R/S)-II derived from 1,8-naphthaldehydic Me ester, followed by cyclization and substitution at the sulfur atom. The products were obtained in 25-98% yield and with enantiomeric excess of 46-99%.

Tetrahedron Letters published new progress about Addition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mendes, Joseane A.’s team published research in Journal of Organic Chemistry in 2019-02-15 | CAS: 343338-28-3

Journal of Organic Chemistry published new progress about Addition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Mendes, Joseane A. published the artcileEnantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias, Product Details of C4H11NOS, the main research area is diastereoselective addition magnesium bromide chiral imine tetralone type ketone; dibenzo azaspirodecane preparation sulfinamide derivative intermediate arylation; azaspiro compound DFT calculation antineoplastic activity drug resistant leukemia.

The addition of 2-bromobenzylmagnesium bromide to chiral N-tert-butanesulfinyl imines derived from tetralone-type ketones proceeds with high levels of diastereocontrol. The resulting sulfinamide derivatives were transformed into dibenzoazaspiro compounds after a palladium-catalyzed intramol. N-arylation. DFT calculations have been performed to rationalize the stereochem. course of the reaction. Similar results have been obtained considering either di-Et ether or toluene as a solvent, in both cases in an excellent agreement with exptl. findings. NCI topol. calculations have also been used to evidence crucial noncovalent interactions. In addition, the azaspiro compounds reduced the viability of chronic myeloid leukemia cells in the micromolar range. Notably, both the halogen-substituted (R)- and (S)-I (R = F, X = CH2) and I (R = Br, X = CH2) as well as (R)-I (R = H, X = S) were at least two times more effective on a multidrug-resistant derivative than on the parental cell line, exerting a collateral sensitivity effect.

Journal of Organic Chemistry published new progress about Addition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nie, Xiao-Di’s team published research in Organic Chemistry Frontiers in 2020 | CAS: 343338-28-3

Organic Chemistry Frontiers published new progress about Addition reaction catalysts (SmI2). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Nie, Xiao-Di published the artcileA diastereoselective approach to amino alcohols and application for divergent synthesis of dolastatin 10, Formula: C4H11NOS, the main research area is amino alc enantioselective diastereoselective synthesis; chiral imine radical addition benzyloxymethylsulfonyl pyridine catalyst samarium diiodide; dolastatin synthesis antitumor agent chirality peptide coupling.

A diastereoselective approach to obtain amino alcs. through SmI2-induced radical addition of chiral imine with 2-(benzyloxymethylsulfonyl)pyridine is described. This approach was easily used for the synthesis of non-natural amino acid (I) hydrochloride, a flexible key fragment whose utility was demonstrated in the divergent synthesis of dolastatin 10 and its nine analogs were obtained.

Organic Chemistry Frontiers published new progress about Addition reaction catalysts (SmI2). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Carotti, Angelo’s team published research in Quantitative Structure-Activity Relationships in 1989-03-31 | CAS: 35203-88-4

Quantitative Structure-Activity Relationships published new progress about Arenesulfonamides Role: USES (Uses). 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Computed Properties of 35203-88-4.

Carotti, Angelo published the artcileInhibition of carbonic anhydrase by substituted benzenesulfonamides. A reinvestigation by QSAR and molecular graphics analysis, Computed Properties of 35203-88-4, the main research area is carbonic anhydrase inhibitor benzenesulfonamide QSAR.

The inhibition of bovine carbonic anhydrase B by an appropriately designed set of m- and p-substituted benzenesulfonamides (I, R = H, halo, alkoxy, aryl, etc.) was studied. From the results the following quant. structure-activity relationship was derived: log 1/Ki = 0.95σ + 0.54π – 0.35B5,3 + 6.29. In this equation Ki is the inhibition constant, σ is the Hammett constant, π is the hydrophobic parameter and B5,3 is the sterimol steric parameter for the m-substituents. Using this equation, a new congener was designed and synthesized and the Ki for a new congener intended to maximize the inhibitory potency (1/Ki) was predicted. The interactions involved in the enzyme-inhibitors binding as suggested by the correlation equation, have been tentatively interpreted using computer built 3-D mol. models based on the published X-ray crystallog. coordinates of the free and inhibitor-bound carbonic anhydrase. The results from our analyses have been compared with those obtained in some previous QSAR analyses.

Quantitative Structure-Activity Relationships published new progress about Arenesulfonamides Role: USES (Uses). 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Computed Properties of 35203-88-4.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bester, Stephanie M.’s team published research in Science (Washington, DC, United States) in 2020 | CAS: 343338-28-3

Science (Washington, DC, United States) published new progress about Anti-HIV agents (anti-HIV-1 agents). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Bester, Stephanie M. published the artcileStructural and mechanistic bases for a potent HIV-1 capsid inhibitor, Product Details of C4H11NOS, the main research area is GS 6207 preparation antiviral HIV1 capsid inhibitor.

The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby preventing functional disassembly of the capsid shell in infected cells. X-ray crystallog., cryo-electron microscopy, and hydrogen-deuterium exchange experiments revealed that GS-6207 tightly binds two adjoining capsid subunits and promotes distal intra- and inter-hexamer interactions that stabilize the curved capsid lattice. In addition, GS-6207 interferes with capsid binding to the cellular HIV-1 cofactors Nup153 and CPSF6 that mediate viral nuclear import and direct integration into gene-rich regions of chromatin. These findings elucidate structural insights into the multimodal, potent antiviral activity of GS-6207 and provide a means for rationally developing second-generation therapies.

Science (Washington, DC, United States) published new progress about Anti-HIV agents (anti-HIV-1 agents). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Kaixuan’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 123-39-7

Chemical Communications (Cambridge, United Kingdom) published new progress about 1,3-Dipolar cycloaddition catalysts. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Wang, Kaixuan published the artcileCatalytic asymmetric [3+2] cycloaddition of isomunchnones with methyleneindolinones, Application of N-Methylformamide, the main research area is chiral oxa bridged spiropiperidine oxindole preparation enantio diastereoselective; diazoimide methyleneindolinone dipolar cycloaddition rhodium zinc catalyst.

An efficient enantioselective [3+2] cycloaddition of isomunchnones with methyleneindolinones that are generated by an in situ intramol. addition of the carbonyl group to rhodium carbenes is realized with a chiral N,N’-dioxide/Zn(II) complex as a Lewis acid. A series of chiral oxa-bridged 3-spiropiperidines are obtained in high yields with excellent dr and excellent ee values.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1,3-Dipolar cycloaddition catalysts. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bendelsmith, Andrew J.’s team published research in Journal of the American Chemical Society in 2019-07-24 | CAS: 343338-28-3

Journal of the American Chemical Society published new progress about Allylation kinetics (stereoselective). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Bendelsmith, Andrew J. published the artcileEnantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis, Synthetic Route of 343338-28-3, the main research area is chloro glycinate enantioselective allylation squaramide catalyst allylstannane allylsilane; allyl amino ester chiral preparation.

Chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of α-allyl amino esters is reported. The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allylation of readily accessible α-chloro glycinates. A variety of useful α-allyl amino esters were prepared, including crotylated products bearing vicinal stereocenters that are inaccessible through enolate alkylation, with high enantioselectivity (up to 97% ee) and diastereoselectivity (>10:1). The reactions display 1st-order kinetic dependence on both the α-chloro glycinate and the nucleophile, consistent with rate-limiting C-C bond formation. Computational anal. of the uncatalyzed reaction predicts an energetically inaccessible iminium intermediate, and a lower energy concerted SN2 mechanism.

Journal of the American Chemical Society published new progress about Allylation kinetics (stereoselective). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xiao, Miao’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 343338-28-3

Angewandte Chemie, International Edition published new progress about Alkylation catalysts, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Xiao, Miao published the artcileTransition-Metal-Free Hydrogen Autotransfer: Diastereoselective N-Alkylation of Amines with Racemic Alcohols, Quality Control of 343338-28-3, the main research area is diastereoselective alkylation amines alc chiral amine synthesis; alcohols; alkylation; amines; deuterium; reaction mechanisms.

A practical method for the synthesis of α-chiral amines by alkylation of amines with alcs. in the absence of any transition-metal catalysts has been developed. Under the co-catalysis of a ketone and NaOH, racemic secondary alcs. reacted with Ellman’s chiral tert-butanesulfinamide by a hydrogen autotransfer process to afford chiral amines with high diastereoselectivities (up to >99:1) [e.g., 1-phenylethanol + (R)-(+)-tert-butanesulfinamide → I (70%, > 95:5 d.r.) in presence of acetophenone and NaOH in toluene]. Broad substrate scope and up to a 10 g scale production of chiral amines were demonstrated. The method was applied to the synthesis of chiral deuterium-labeled amines with high deuterium incorporation and optical purity, including examples of chiral deuterated drugs. The configuration of amine products is found to be determined solely by the configuration of the chiral tert-butanesulfinamide regardless of that of alcs., and this is corroborated by DFT calculations Further mechanistic studies showed that the reaction is initiated by the ketone catalyst and involves a transition state similar to that proposed for the Meerwein-Ponndorf-Verley (MPV) reduction, and importantly, it is the interaction of the sodium cation of the base with both the nitrogen and oxygen atoms of the sulfinamide moiety that makes feasible, and determines the diastereoselectivity of, the reaction.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Meddeb, Amira Barhoumi’s team published research in MRS Advances in 2020 | CAS: 123-39-7

MRS Advances published new progress about Cholesteric liquid crystals, polymeric. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Meddeb, Amira Barhoumi published the artcileFrom a cholesteric non-aqueous cellulose nanocrystal suspension to a highly ordered film, Formula: C2H5NO, the main research area is cellulose nanocrystal methylformamide film non aqueous suspension magnetic anisotropy.

A highly ordered cellulose nanocrystal (CNC) film was processed and characterized from a non-aqueous suspension. As a first step, by drawing upon the neg. magnetic anisotropy of CNCs, a global order of the nanocrystals is achieved by magnetic field-assisted manipulation of a cholesteric suspension in n-methylformamide (NMF), and then the order is subsequently preserved into a solid-state film. We study the differences between the structures of the 4 T-dried film and the control film dried in the absence of magnetic field. Addnl., we compare the NMF-dried films to those dried from aqueous suspensions with and without magnetic field. Optical microscopy, cross-sectional imaging anal., and sum frequency generation (SFG) spectroscopy show that the CNC-NMF film dried under magnetic field exhibited a highly ordered layered structure throughout the film, comparable to that observed when films were produced from aqueous suspensions. Extending the potential of the CNC alignment to non-aqueous systems will enable a broad spectrum of applications for CNC-based polymer composites.

MRS Advances published new progress about Cholesteric liquid crystals, polymeric. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Aynehband, Samaneh’s team published research in New Journal of Chemistry in 2021 | CAS: 123-39-7

New Journal of Chemistry published new progress about Electric current-potential relationship. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Aynehband, Samaneh published the artcileEfficient FAPbI3-PbS quantum dot graphene-based phototransistors, Safety of N-Methylformamide, the main research area is formamidinium lead iodide sulfide quantum dot graphene phototransistor.

The high mobility of charge carriers in graphene (G) together with the ease of processing and tunable optical properties of colloidal quantum dots (CQD) has provided high-performance hybrids for the next generation of phototransistors. In order to get a higher quality film of PbS QDs, understanding the effect of the ligand exchange method is critical So, to improve the interdot electronic coupling, we propose a new conducting ligand to prepare a dense and self-assembled active layer of FAPbI3-PbS quantum dots on G/Si/SiO2 substrates. Quantum dot (QD) nanocrystalline films were prepared via two different procedures: liquid phase ligand exchange (LPE) and solid phase ligand exchange (SPE). SPE with formamidinium lead iodide significantly increases the packing d. and surface coverage of the active layer on the graphene substrate. Efficient light absorption in the near IR region and reduced charge transport resistance in the QD film are demonstrated. The SPE fabricated graphene-based heterostructure phototransistors exhibit improved specific detectivity (by 34%) and ION/IOFF ratio (by 23%) as compared with LPE. Our findings pave a way to develop high-throughout graphene-based phototransistors based on FAPbI3-CQDs.

New Journal of Chemistry published new progress about Electric current-potential relationship. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics