Month: November 2022

Schaad, David R. published the artcileReactions of amides with zerovalent and divalent palladium and platinum complexes, Quality Control of 359-38-6, the main research area is methylplatinum photosubstitution amide triflamide trifluoroacetamide; methylpalladium photosubstitution amide triflamide trifluoroacetamide; palladium zerovalent divalent amide; platinum zerovalent divalent amide; hydroamination catalysis amidepalladium amideplatinum.

The reactions of amides (RCONH2 and CF3SO2NH2) with L2Pd(CH3)2 and L2Pt(CH3)2 and with transient L2Pt(0) to yield new complexes containing palladium- and platinum-amido nitrogen bonds are reported. Photolysis of Pt(C2O4)(PEt3)2 in the presence of amide generates products of the type trans-PtH(HNR)(PEt3)2 [R = SO2CF3 (1a), COCF3 (1b)]. Reaction of amides with trans-PtH(CH3)(PEt3)2 (2), cis-PdMe2(PEt3)2 (3), cis-PtMe2(PEt3)2 (4), PdMe2(dcpe) (5), PdMe2(dmpe) (6), and PtMe2(COD) (7) produces 1a,b, trans-PdMe(HNR)(PEt3)2 [R = SO2CF3 (3a), COCF3 (3b), COCF2H (3c), COPh (3d)], PtMe(HNR)(PEt3)2 [R = SO2CF3 (4a), COCF3 (4b)], PdMe(HNR)(dcpe) [R = SO2CF3 (5a), COCF3 (5b), COPh (5c)], PdMe(HNSO2CF3)(dmpe) (6a), and PtMe(HNR)(COD) [R = SO2CF3 (7a), COCF3 (7b)], resp. The stereochem. and topologies of the new compounds are established by multinuclear NMR spectroscopy. The relevance of these reactions to hydroaminium catalysis is discussed.

Organometallics published new progress about Coordinative photosubstitution reaction. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Quality Control of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cancelada, Lucia published the artcileHeated Tobacco Products: Volatile Emissions and Their Predicted Impact on Indoor Air Quality, Quality Control of 123-39-7, the main research area is heated tobacco product volatile emission indoor air pollution; IQOS apparatus heated tobacco product.

This work characterized emissions from IQOS, a heated tobacco product promoted as a less harmful alternative to cigarettes. Consumable tobacco plugs were analyzed by headspace gas chromatog./mass spectrometry to assess the heating temperature effect on the emission profile. Yields of major chem. constituents increased from 4.1 mg/unit at 180° to 6.2 mg at 200°, and 10.5 mg at 220°. The Health Canada Intense smoking regime was used to operate IQOS in an environmental chamber, quantifying 33 volatile organic compounds in mainstream and side-stream emissions. Aldehydes, nitrogenated species, and aromatic species were observed as were other harmful and potentially harmful compounds Compared to combustion cigarettes, IQOS yields were, in most cases, 1-2 orders of magnitude lower; however, yields were closer to and sometimes higher than, electronic cigarettes. Predicted user daily average benzene, formaldehyde, acetaldehyde and acrolein intakes were 39, 32, 2.2, and 71 μg, resp. Indoor air concentrations were estimated for commonly encountered scenarios, with acrolein levels of concern (>0.35 μg/m3) derived from IQOS used in homes and public spaces. Heated tobacco products are a weaker indoor pollution source than conventional cigarettes, but their impacts are not negligible nor fully understood.

Environmental Science & Technology published new progress about Apparatus (IQOS tobacco product heating). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zeng, Cui-Lian published the artcileCF3SO2Na-Mediated Visible-Light-Induced Cross-Dehydrogenative Coupling of Heteroarenes with Aliphatic C(sp3)-H Bonds, Safety of N-Methylformamide, the main research area is quinoline cross dehydrogenative coupling visible light Minisci type reaction; alkyl quinoline preparation.

Minisci-type reaction is one of the important means to construct C(sp3)-H functionalization of heteroarenes. According to traditional methods, stoichiometric amounts of precious transition metal catalysts and chem. oxidants were required at high temperatures Here, a green and gentle novel Minisci-type method was developed via visible-light-induced cross-dehydrogenative coupling of heteroarenes with aliphatic C(sp3)-H bonds under oxidant-free and transition-metal-catalyst-free conditions. Only the catalytic equivalent of CF3SO2Na and room temperature were required to maintain an efficient reaction.

Organic Letters published new progress about Coupling reaction (cross-dehydrogenative). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Flores-Holguin, Norma published the artcileConceptual DFT-Based Computational Peptidology, Pharmacokinetics Study and ADMET Report of the Veraguamides A-G Family of Marine Natural Drugs, Application of N-Methylformamide, the main research area is veraguamide natural drug density functional theory pharmacokinetics computational peptidol; ADMET; KID (Koopmans In DFT); Veraguamides A–G; computational peptidology; computational pharmacokinetics; conceptual DFT.

As a continuation of our research on the chem. reactivity, pharmacokinetics and ADMET properties of cyclopeptides of marine origin with potential therapeutic abilities, in this work our already presented integrated mol. modeling protocol has been used for the study of the chem. reactivity and bioactivity properties of the Veraguamides A-G family of marine natural drugs. This protocol results from the estimation of the conceptual d. functional theory (CDFT) chem. reactivity descriptors together with several chemoinformatics tools commonly considered within the process of development of new therapeutic drugs. CP-CDFT is a branch of computational chem. and mol. modeling dedicated to the study of peptides, and it is a protocol that allows the estimation with great accuracy of the CDFT-based reactivity descriptors and the associated phys. and chem. properties, which can aid in determining the ability of the studied peptides to behave as potential useful drugs. Moreover, the superiority of the MN12SX d. functional over other long-range corrected d. functionals for the prediction of chem. and phys. properties in the presence of water as the solvent is clearly demonstrated. The research was supplemented with an investigation of the bioactivity of the mol. systems and their ADMET (absorption, distribution, metabolism, excretion, and toxicity) parameters, as is customary in medicinal chem. Some instances of the CDFT-based chem. reactivity descriptors’ capacity to predict the pKas of peptides as well as their potential as AGE inhibitors are also shown.

Marine Drugs published new progress about Advanced glycation end product inhibitors. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gao, Xiaoyi published the artcileA novel solid-liquid ‘phase controllable’ biphasic amine absorbent for CO2 capture, COA of Formula: C2H5NO, the main research area is solid liquid phase controllable biphasic amine absorbent; carbon dioxide capture.

The main issues in the application of biphasic amine absorbent include the inconvenient separation of the liquid-liquid biphase and the clogging that is associated with the solid-liquid mixture A novel solid-liquid ‘phase controllable’ biphasic amine absorbent was therefore developed, in which the phase separation occurred only when the absorbent was near saturation The absorbent, composed of triethylene tetramine (TETA), 2-amino-2-methyl-1-propanol (AMP), and N-methylformamide (NMF), turned into solid-liquid biphase under CO2 loading of 0.85 mol mol-1, which is close to saturation (0.92 mol mol-1). The solid phase comprised white powder that accounted for only 42% of the total volume while absorbing 91% of the total load. Turbidity and particle size tests showed that the phase separation was self-aggregating. The mechanisms of absorption and regulation were obtained using 13C NMR and mol. simulation. During the absorption, CO2 first combined with TETA to generate TETAH+CO-2/TETACO-2 through the zwitterion mechanism, and then combined with AMP to generate AMPCO-2 because of the lower reaction activity between CO2 and AMP. The TETA-carbamate was found to greatly weakened the strength of the hydrogen bonds and the van der Waals forces between AMPH+ and AMPCO-2, increasing the solubility of the intermediate products, and therefore achieved the purpose of controlling the phases separation inherent in the reaction.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Absorbents (solid-liquid biphasic, amine). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Han, Jie published the artcileDesign and Synthesis of WJ-Phos, and Application in Cu-Catalyzed Enantioselective Boroacylation of 1,1-Disubstituted Allenes, Synthetic Route of 343338-28-3, the main research area is ferrocene chiral sulfinamide phosphine enantioselective catalyst boroacylation allene; crystal structure mol ferrocene chiral sulfinamide phosphine preparation ligand.

The highly enantioselective copper-catalyzed three-component boroacylation of 1,1-disubstituted allenes is reported by using a class of chiral ligands (WJ-Phos), delivering various functionalized organoboron compounds bearing an all-carbon stereocenter in moderate to good yields with high enantioselectivities. WJ-Phos is a ferrocene-derived chiral sulfinamide phosphine ligand and can be easily synthesized in gram-scale from readily available starting materials in short steps. The salient features of this reaction include moderate to good yields, high enantioselectivities, gram-scale synthesis, diverse synthetic transformations, and the development of a new chiral ligand.

ACS Catalysis published new progress about Acylation (boroacylation, stereoselective). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

You, Ge-Yun published the artcileSimple chiral sulfinyl imine-thioether ligands for Pd-catalyzed allylic alkylation, Quality Control of 343338-28-3, the main research area is chiral sulfnyl imine thioether ligand preparation; diester biphenyl allylacetate palladium sulfnyl iminethioether catalyst allylic alkylation; biphenyl allyl ester enantioselective preparation.

A set of chiral sulfinyl imine-thioether ligands were prepared via dehydration condensation of substituted benzaldehyde and chiral sulfinamide. The activity of these ligands in Pd-catalyzed asym. allylic alkylation reaction was studied, and the results indicate that the structure of sulfinamide motifs has an obvious effect on the e.r. value and yield. The chiral p-tolylsulfinamide derived ligands can promote the reaction efficiently, while the ligands with tert-Bu group fail to catalyze the reaction. Then, the substrate scope was also investigated under the optimal reaction conditions.

Chemical Papers published new progress about Allylic alkylation catalysts, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Noori, Abdolvahed published the artcileQuorum quenching bacteria isolated from industrial wastewater sludge to control membrane biofouling, Recommanded Product: N-Methylformamide, the main research area is quorum quenching bacteria industrial wastewater sludge membrane biofouling; Biofouling; Industrial wastewater; Quorum quenching; Quorum sensing; Tetramethylammonium hydroxide.

N-acylhomoserine lactone (AHL)-based bacterial communication through quorum sensing (QS) is one of the main causes of biofouling. Although quorum quenching (QQ) has proven to be an effective strategy against biofouling in membrane bioreactors (MBRs) for municipal wastewater treatment, its applicability for industrial wastewater treatment has rarely been studied. This is the first study to isolate QQ strains from the activated sludge used to treat industrial wastewater containing toxic tetramethylammonium hydroxide (TMAH) and 1-methyl-2-pyrrolidinone. The two QQ strains from genus Bacillus (SDC-U1 and SDC-A8) survived and effectively degraded QS signals in the presence of TMAH. They also showed resistance to toxic byproducts of TMAH degradation such as ammonium and formaldehyde. They effectively reduced the biofilm formation of Pseudomonas aeruginosa PAO1 and mixed community of activated sludge. The strains isolated in this study thus have the potential to be employed to reduce membrane biofouling in MBRs during the treatment of TMAH-containing wastewater.

Bioresource Technology published new progress about Activated-sludge process wastewater treatment. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Bo-Han published the artcileRegio- and Stereoselective Synthesis of Diverse 3,4-Dihydro-2-quinolones through Catalytic Hydrative Cyclization of Imine- and Carbonyl-Ynamides with Water, HPLC of Formula: 343338-28-3, the main research area is dihydro quinolone preparation stereoselective regioselective; imine ynamide tandem Mannich reaction copper catalyst; carbonyl ynamide aldol reaction zinc catalyst.

Described herein is an efficient copper-catalyzed tandem alkyne hydration/intramol. Mannich reaction of imine-ynamides 2-N(R)CCR1-4-R2-5-R3C6H2CH=NR4 (R = Ts, 4-bromobenzenesulfonyl; R1 = Me, allyl, Ph, etc.; R2 = H, F, Cl, Me, OMe; R3 = H, Me, Br; R4 = Ts, tert-butylsulfonyl, 2-methylpropane-2-sulfinyl) with water. This method allows efficient and diastereodivergent synthesis of valuable 3,4-dihydro-2-quinolones I with high regio-, diastereo-, and enantioselectivity. Moreover, this hydrative cyclization can also be applicable to the hydrative aldol reaction of carbonyl-ynamides 2-N(R)CCR1-4-R2-5-R3C6H2C(O)R5 (R = Ts, Ms, 4-bromobenzenesulfonyl; R5 = H, Me, Ph) with water to form 3,4-dihydro-2-quinolones II regio- and diastereoselectively by employing zinc as the catalyst.

ACS Catalysis published new progress about Aldol addition, stereoselective (regioselective). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kowalczyk, Agata published the artcileEnantioselective sensing of (S)-Thalidomide in blood plasma with a chiral naphthalene diimide derivative, Formula: C4H11NOS, the main research area is thalidomide enantioselective sensing blood plasma chiral naphthalene diimide derivative; Chiral naphthalene diimide; Chiral recognition modeling; Thalidomide; Voltammetric enantiosensor.

Fast, simple in use and highly effective voltammetric enantiosensor dedicated for determination of thalidomide (TD) enantiomers (especially towards the toxic (S)-enantiomer) in blood plasma is still desirable. Here we have proven that newly synthesized chiral naphthalene diimide (NDI) derivatives are excellent electroactive materials for TD enantiosensors. The recognition process relies on the specific interaction between the chiral NDI receptor and the thalidomide enantiomer of the opposite configuration. This unique specific interaction between (S)-thalidomide and (R)-NDI derivative counterparts, evident in the DPV voltammograms, was confirmed by mol. modeling. The demonstrated voltammetric enantiosensors are characterized by the low detection limit at the level of μg·L-1, wide anal. range from 5·10-4 – 10 mg·L-1, high selectivity and long lifetime. The results of the recovery rates showed a very good degree of accuracy towards the determination of (S)-thalidomide in the blood samples, so it can be successfully used in the anal. of clin. samples.

Biosensors & Bioelectronics published new progress about Bioelectric current, current-potential relationship. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics