Month: November 2022

Reitz, David B. published the artcile1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560, Application of 3-Bromoisonicotinamide, the main research area is triazole angiotensin receptor antagonist preparation structure; phenylpyridinylmethyl triazole angiotensin receptor antagonist preparation; pyridinylphenylmethyl triazole angiotensin receptor antagonist preparation; antihypertensive triazole angiotensin receptor antagonist structure.

Substituting nitrogen for carbon in the four pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental to the angiotensin II receptor-antagonist activity; however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior in vivo properties in the rat angiotensin II pressor assay.

Bioorganic & Medicinal Chemistry Letters published new progress about Angiotensin receptors Role: BIOL (Biological Study). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, Application of 3-Bromoisonicotinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nishimura, Kazuki published the artcileThorpe-Ingold Effect on High-Performance Chiral π-Copper(II) Catalyst, Product Details of C4H11NOS, the main research area is dimethylpyrazole preparation enantioselective.

The Thorpe-Ingold effect was applied to the design of a chiral ligand of π-copper(II) catalysts for the enantioselective α-fluorination of 1-(3,5-dimethyl-pyrazol-1-yl)-2-phenyl-ethanone, and also for the enantioselective Mukaiyama-Michael, Diels-Alder, and 1,3-dipolar cycloaddition reactions of N-acryloyl-3,5-dimethylpyrazoles I (R = Bn, ethynyl, ethenyl, etc.). The use of β,β-dimethyl-β-arylalanine-type ligand gave desired products e.g., II with higher enantioselectivity compared to with previously reported β-arylalanine-type ligands.

Synlett published new progress about 1,3-Dipolar cycloaddition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Mingkai published the artcileStereocontrolled Pericyclic and Radical Cycloaddition Reactions of Readily Accessible Chiral Alkenyl Diazaborolidines, Application In Synthesis of 343338-28-3, the main research area is crystal structure mol chiral alkenyl diazaborolidine preparation; stereoselective pericyclic radical cycloaddition chiral alkenyl diazaborolidine; Boron; Cycloaddition; Photoredox Catalysis; Stereoselectivity.

In this paper is described an easily synthesized chiral diazaborolidine that is inexpensive, stable, and provides excellent stereoselection across a number of reaction classes. These versatile compounds possess utility in four different classes of cycloaddition reactions, offering good yield and stereoselectivity. X-ray structure anal. provides insight about the origin of stereocontrol.

Angewandte Chemie, International Edition published new progress about 1,3-Dipolar cycloaddition reaction, stereoselective. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application In Synthesis of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Uphade, Manoj B. published the artcileStereoselective Addition of a Lithium Anion of 1,1-Diphenyl-2-aza-pentadiene to Sulfinimines: Application to the Synthesis of (-)-Epiquinamide, Formula: C4H11NOS, the main research area is total synthesis epiquinamide; stereoselective addition lithiated azapentadiene sulfinimine vicinal diamine synthesis.

The addition of a lithium anion of diphenylallylimine to nonracemic sulfinimines was investigated. It was found that the reaction with sulfinimines derived from aliphatic aldehydes afforded the products with excellent diastereoselectivity (>99:1), furnishing the product vicinal diamines in very good yields. Application of the formed product vicinal diamines was demonstrated in the total synthesis of the natural product (-)-epiquinamide.

Organic Letters published new progress about Addition reaction, regioselective (α- vs. γ-addition). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Falcinelli, Stefano published the artcileThe Fragmentation Dynamics of Simple Organic Molecules of Astrochemical Interest Interacting with VUV Photons, Product Details of C2H5NO, the main research area is propylene oxide methylformamide vacuum extreme UV double photoionization fragmentation.

An exptl. investigation on the fragmentation dynamics following the double photoionization of simple organic mols. of astrochem. interest, propylene oxide and N-methylformamide mols., induced by VUV photons has been reported. Experiments used linearly polarized light in the 18-37 eV (propylene oxide) and 26-45 eV (N-methylformamide) photon energy range at the ELETTRA Synchrotron Facility of Trieste (Italy), coupling ion imaging and electron-ion-ion coincidence techniques with time-of-flight mass spectrometry. In the case of propylene oxide, six different two-body fragmentation processes have been recorded with the formation of CH2+/C2H4O+, CH3+/C2H3O+, O+/C3H6+, OH+/C3H5+, C2H3+/CH3O+, C2H4+/CH2O+ ion pairs. On the other hand, the double photoionization of N-methylformamide occurs producing two main fragmentation reactions, forming CH3+ + CH2NO+ and H+ + C2H4NO+. The relative cross sections and the threshold energies for all fragmentation channels are recorded as a function of the photon energy. Furthermore, in the case of the double photoionization of propylene oxide, the measure of the kinetic energy released distribution for the CH3+/C2H3O+ final ions with their angular distributions allowed the identification of a bimodal behavior indicating the possible formation of two different stable isomers of C2H3O+: acetyl and oxiranyl cations. The obtained results are important to clarify the phys. chem. of the elementary processes induced by the interaction of ionizing radiations with simple organic mols. of astrochem. interest: propylene oxide and N-methylformamide.

ACS Earth and Space Chemistry published new progress about Angular distribution function (kinetic energy release). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xiong, Yang published the artcileVisible Light-Mediated Dearomative Hydrogen Atom Abstraction/ Cyclization Cascade of Indoles, Product Details of C2H5NO, the main research area is oxospiro dioxospiro dihydrospiro indoline preparation photochem; indole amine dearomative hydrogen transfer spirocyclization tandem reaction; C−H Activation; Heterocycles; Hydrogen Transfer; Photochemistry; Sensitizers.

The photochem. synthesis of yet unknown 2-oxospiro[azetidine-3,3′-indolines] (17 examples, 80-95% yield), 2,4-dioxospiro[azetidine-3,3′-indolines] (eight examples, 87-97% yield), and 1-oxo-1,3-dihydrospiro[indene-2,3′-indolines] (17 examples, 85-97% yield) is described. Starting from readily accessible 3-substituted indoles, a dearomatization of the indole core was accomplished upon irradiation at λ=420 nm in the presence of thioxanthen-9-one (10 mol%) as the sensitizer. Based on mechanistic evidence (triplet energy determination, deuteration experiments, byproduct anal.) it is proposed that the reaction proceeds by energy transfer via a 1,4- or 1,5-diradical intermediate. The latter intermediates are formed by excited state hydrogen atom transfer from suitable alkyl groups within the C3 substituent to the indole C2 carbon atom. Subsequent ring closure proceeds with pronounced diastereoselectivity to generate a 4- or 5-membered spirocyclic dearomatized product with several options for further functionalization.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joseph, Devaneyan published the artcileMetal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is benzoylpyrrolidinone benzoylpiperidinone benzoylazepanone amine transamidation green chem.

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jin, Hao published the artcileTransition-Metal-Free, General Construction of Thioamides from Chlorohydrocarbon, Amide and Elemental Sulfur, Related Products of amides-buliding-blocks, the main research area is thioamide preparation; chlorohydrocarbon amide sulfur coupling three component reaction.

A general method for one-pot synthesis of thioamides is developed through a three-component reaction involving chlorohydrocarbon, amide and elemental sulfur. Such a strategy does not only avoid residual transition metal in the product but also prevent the generation of C-N coupling byproduct. The latter is prone to be generated when alkane halide and amine are present. With the protocol proposed in this work, both alkyl and aryl thioamides can be obtained in moderate to excellent yields with a high tolerance of various functional groups. External oxidants are not required in the reaction. In addition, the reaction mechanisms are addressed using a combination of controlling experiments and quantum chem. calculations

European Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bonciolini, Stefano published the artcileA scalable continuous photochemical process for the generation of aminopropylsulfones, Recommanded Product: N-Methylformamide, the main research area is aminopropylsulfone preparation; amide vinyl sulfone coupling reaction tetrabutylammonium decatungstate photocatalyst.

An efficient continuous photochem. process that delivers a series of novel γ-aminopropylsulfones RSO2CH2CH2CH(R1)N(R2)C(O)R3 (R = Ph, Et; R1 = H, Me; R2 = Me, Et; R3 = H, Ph, cyclohexyl, etc.) and RSO2CH2CH2CH(O)NHMe via a tetrabutylammonium decatungstate (TBADT) catalyzed HAT-process is presented. Crucial to this success is the exploitation of a new high-power LED emitting at 365 nm that was found to be superior to an alternative medium-pressure Hg lamp. The resulting flow process enabled the scale-up of this transformation reaching throughputs of 20 mmol h-1 at substrate concentrations up to 500 mM. Addnl., the substrate scope of this transformation was evaluated demonstrating the straightforward incorporation of different amine substituents as well as alkyl appendages next to the sulfone moiety. It is anticipated that this methodol. will allow for further exploitations of these underrepresented γ-aminopropylsulfone scaffolds in the future.

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jin, Hao published the artcileGeneral Construction of Thioamides under Mild Conditions: A Stepwise Proton Transfer Process Mediated by EDTA, Application of N-Methylformamide, the main research area is thioamide preparation green chem DFT; ester amide sulfur one pot coupling EDTA catalyst.

A general and clean method for the one-pot synthesis of thioamides, e.g., I, was investigated using a combination of experiments and quantum chem. calculations Esters RCH2OCHO (R = Pr, cyclohexyl, Ph, etc.), amides, e.g., 4-morpholinecarboxaldehyde and elemental sulfur were employed as starting materials and ethylene diamine tetraacetic acid (EDTA) as catalyst. Both alkyl and aryl thioamides with various functional groups were obtained in moderate to good yields. Neither transition metals nor external oxidants were required in this reaction. The catalytic performance of EDTA originates from a stepwise, proton transfer process in which EDTA transports a proton from the benzyl carbon to a sulfur atom. Such a process is concerted by discrete charge transfer such that the associated barrier gets lowered.

European Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics