Month: November 2022

Lei, Peng published the artcileProtocol for Palladium/N-Heterocyclic Carbene-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation, Quality Control of 7465-88-5, the main research area is diaryl ketone green preparation; amide arylboronic acid Suzuki Miyaura cross coupling palladium catalyst.

A protocol for the Suzuki-Miyaura cross-coupling of amides by selective N-C(O) bond activation catalyzed by com. available, air- and moisture-stable palladium/N-heterocyclic carbene (NHC) complexes was described to obtain diaryl ketones ArC(O)Ar1 [Ar = Ph, 2-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4; Ar1 = Ph, 2-MeC6H4, 4-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4]. The procedure described involved [Pd(IPr)(cin)Cl] [IPr = 2,6-(diisopropylphenyl)imidazol-2-ylidene, cin = cinnamyl] at 0.10 mol% at room temperature and was performed on decagram scale. Furthermore, a procedure for the synthesis of amide starting materials was accomplished via selective N- tert-butoxycarbonylation, which was the preferred method over N-acylation. The present protocol carried advantages of operational simplicity, com. availability of catalysts and excellent conversions at low catalyst loadings. The method was generally useful for activation of N-C(O) amide bonds in a broad spectrum of amide precursors. The protocol should facilitate the implementation of amide cross-coupling reactions.

Synthesis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Rong published the artcileActivated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is aryl benzamide preparation; primary amide aryl iodide Goldberg reaction copper catalyst; lactam aryl iodide Goldberg reaction copper catalyst.

A novel heterogeneous copper catalyst has been developed by supporting copper nanoparticles on activated charcoal via in situ reducing copper(II) with aqueous hydrazine as reductant. The characterization of Cu/C catalyst showed that the Cu0 nano-particles were formed on the surface of charcoal. This catalyst displayed good catalytic activities toward the N-arylation of primary amides RC(O)NH2 (R = Ph, pyridin-3-yl, 3-nitrophenyl, etc.) and lactams such as 3-morpholinone, 2-azaspiro[4.5]decan-1-one, 2-pyridinone with aryl iodides 4-R1C6H4I (R1 = H, OMe, Ac, Br, NO2).

Tetrahedron published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Nan published the artcileA Strategy for Amide to β-Oxo Ester Transformation via N-Alkenoxypyridinium Salts as the Activator and H2O as the Nucleophile, Name: N-Methylformamide, the main research area is amide alkenoxypyridinium salt water coupling; ester oxo preparation.

N-Alkenoxypyridinium salts were found to be highly active electrophilic reagents that could be used to activate the C-N bond of amides. Both aromatic amides and aliphatic amides could be transformed into the corresponding β-oxo esters with good yields via the combined use of N-alkenoxypyridinium salts and water. The methodol. proceeds under mild reaction conditions and is tolerant of various functional groups in both reaction partners.

Organic Letters published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Magsumov, Timur I. published the artcileDevelopment of Abraham model correlations for enthalpies of solvation of solutes dissolved in N-methylformamide, 2-pyrrolidone and N-methylpyrrolidone, Related Products of amides-buliding-blocks, the main research area is methylformamide pyrrolidone methylpyrrolidone solute solvation enthalpy Abraham model correlation.

Enthalpies of solution at infinite dilution have been determined for 2-propanol, ethylene glycol, 1,3-butanediol, 1,4-butanediol, phenol, 1-naphthol, 3-nitrophenol, 4-nitrophenol, 4-chlorophenol, and formamide dissolved in N-methylformamide, 2-pyrrolidone, and N-methylpyrrolidone at 298.15 K, as well as for N-methylformamide dissolved in 2-pyrrolidone and N-methylpyrrolidone, based on solution calorimetric measurements. Results of our exptl. measurements, combined with published literature data, have been used to derive Abraham model expressions for predicting the enthalpies of solvation of solutes dissolved in the three fore-mentioned amide solvents. Our derived math. expressions back-calculated the observed enthalpy of solvation data to within a standard deviation of 3.1 kJ mol-1 or less.

Journal of Molecular Liquids published new progress about Amides Role: NUU (Other Use, Unclassified), USES (Uses). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Pei-Chao published the artcilePd/PC-Phos-Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes and N-Allenamides, Name: (S)-2-Methylpropane-2-sulfinamide, the main research area is regioselective enantioselective intermol denitrogenative cyclization benzotriazole allene allenamide; palladium sulfinamide phosphine catalyzed cyclization methyleneindoline preparation; allenamides; allenes; cyclization; heterocycles; palladium.

Reported herein is an asym. Pd/PC-Phos-catalyzed denitrogenative cyclization of benzotriazoles with allenes and N-allenamides, representing the first example of enantioselective denitrogenative cyclizations of benzotriazoles. A series of optically active 3-methyleneindolines were obtained in good yields with high ee values. The use of inexpensive and readily available starting materials, high regio- and enantioselectivity, a broad substrate scope, mild reaction conditions, no need for base, as well as versatile functionalization of the 3-methyleneindolines make this approach attractive.

Angewandte Chemie, International Edition published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Name: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Molaei Yielzoleh, Fatemeh published the artcileTitanomagnetite functionalized by amino acid-based ionic liquid and cobalt (Fe3-xTixO4-SiO2@TrpBu+3I–Co(II)): A reusable bio-nanocomposite for the synthesis of aryl thioamides, Safety of N-Methylformamide, the main research area is cobalt titanomagnetite ionic liquid nanocomposite functionalized amino acid preparation; reusable bio nanocomposite preparation catalyst aryl thioamide; tributyltryptophanium cobalt titanomagnetite ionic liquid bio nanocomposite preparation catalyst.

An efficient and straightforward three-component reaction of alkynes (terminal and internal), elemental sulfur, and amides using novel bio-nanocomposite is described. The bio-nanostructure obtained from step-by-step coating the titanomagnetite core by silica, N,N,N-tributyltryptophanium iodide ionic liquid, and cobalt resp. The Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) characterized though FT-IR, FESEM, EDAX, XRF, TGA/DTG, VSM, and XPS techniques. Its catalytic efficacy examined successfully in the solvent-free three-component reaction of alkynes (terminal and internal), S8, and amides to prepare the corresponding aryl thioamides via the C-C triple bond cleavage. The reusability examination of the Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) bio-nanocomposite proceeded successfully within two runs. The recovered nanostructure characterized through EDAX and FESEM techniques that demonstrated no significant changes in the morphol. and constitutive elements.

Journal of Molecular Structure published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chu, Haoke published the artcileAsymmetric Dearomatization of Indole by Palladium/PC-Phos-Catalyzed Dynamic Kinetic Transformation, HPLC of Formula: 343338-28-3, the main research area is asym dearomatization indole palladium PCPhos catalyzed dynamic kinetic transformation; preparation chiral spiroindolenine; alkynes; catalytic asymmetric dearomatization; chiral spiroindolenine; dynamic kinetic transformation; palladium.

A palladium-catalyzed intermol. dynamic kinetic asym. dearomatization of 3-arylindoles with internal alkynes was developed with the use of achiral Xantphos and chiral sulfinamide phosphine ligand (PC-Phos) as the co-ligands. This method could deliver various spiro[indene-1,3′-indole] compounds in good yields (up to 95% yield) with up to 98% ee. The salient features of the transformation include the use of readily available substrates, ease of scale-up and the versatile functionalization of the products. The mechanistic experiments gave some insights on active intermediates.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yan, Dong published the artcileSBA-15 Supported Chiral Phosphine-Gold(I) Complex: Highly Efficient and Recyclable Catalyst for Asymmetric Cycloaddition Reactions, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is mesoporous silica supported chiral phosphine gold complex preparation; furooxazine preparation enantioselective; alkyne nitrone cycloaddition silica supported gold catalyst.

Ordered mesoporous SBA-15 supported chiral phosphine gold (I) complexes were successfully developed. The gold(I) complexes were covalently immobilized on mercaptopropyl modified silica surface through radical reaction. In this way, the chiral carbon and chiral sulfur of the homogenous catalyst were perfectly remained in situ. And thus, the prepared catalysts demonstrated highly effective asym. cycloaddition activity to afford furooxazines I [R1 = n-Pr, n-Bu, Ph; R2 = Ph; R3 = Ph, 4-MeC6H4; R4 = Ph, 4-BrC6H4], which was likely because the chiral induction effect of the Au complex was hardly influenced by this immobilization method. Moreover, they could be easily recovered by simple filtration and directly used for the subsequent catalytic runs. The prepared catalyst was highly stable and efficient without obvious activity loss after eight cycles.

ChemCatChem published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Rong-Hua published the artcileSelective C(sp3)-H Cleavage of Enamides for Synthesis of 2-Pyridones via Ligand-enabled Ni-Al Bimetallic Catalysis, Application of N-Methylformamide, the main research area is pyridone preparation regioselective; formyl enamide alkyne cyclization nickel aluminum catalyst.

Herein, a selective C(sp3)-H cleavage of N-formyl enamides R(R1)C=C(CH2(R2))N(CHO)R3 [R = H, Me; R1 = H, propan-2-yl, 4-methoxyphenyl, etc.; R2 = H; R1R2 = -((CH2)2)-, -((CH2)3)-, -(CH2CH(C6H5)CH2)-; R3 = Me, n-Pr, Ph, Bn, 3-methylbut-3-en-1-yl] without backbone modification, providing a series of 2-pyridones I [R4 = Me, Ph, thiophen-2-yl, etc.; R5 = n-Bu, Ph, thiophen-2-yl, etc.] in 58-99% yields was reported. A bifunctional phosphine oxide (PO) ligand-bridging Ni-Al bimetallic catalyst played key role in the reaction.

ACS Catalysis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Hao published the artcileEnantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups, Recommanded Product: N-Methylformamide, the main research area is ferrocene based formamide preparation nickel catalyzed oxidative annulation alkyne; chiral benzyldiphenyl ferrocenopyridinone preparation crystal structure; mol structure chiral benzyldiphenyl ferrocenopyridinone; aluminum; annulation; ferrocenes; formamides; nickel.

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved. Ni-Al bimetallic catalysis enabled by a bulky BINOL-derived chiral secondary phosphine oxide (SPO) ligand proved to be critical for high reactivity and high selectivity. This reaction uses readily available formamides as starting materials and provides a concise synthetic pathway to a broad range of chiral ferrocenes in 40-98% yield and 93-99% ee.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics